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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
820 stopped studies mapped to Malignant Colorectal Neoplasm and descendants · 90% state a reason
Over the 820 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02883790 | Effects of Somnage® in the Management on Sleep and Mood in Cancer Patients | N/A | terminated | Aug 30, 2016 | Helsinn Healthcare SA | Low enrolment rate | Enrollment / accrual |
| NCT02605044 | Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With… | Phase 3 | terminated | Nov 16, 2015 | AB Science | Sponsor decision based on portfolio prioritization | Sponsor / business decision |
| NCT01871311 | A Phase I Study of Nilontinib and Cetuximab in Patients With Solid Tumors | Phase 1 | terminated | Jun 6, 2013 | Georgetown University | Primary investigator left the institution. | Investigator |
| NCT01458925 | Feasibility of Check-Cap's P1 Capsule System Screening | N/A | terminated | Oct 25, 2011 | Check-Cap Ltd. | All trials ojectives were met | Other (stated, no rule matched) |
| NCT03717038 | Sym004 Versus TAS-102 in Patients With mCRC | Phase 3 | withdrawn | Oct 23, 2018 | Symphogen A/S | Study was withdrawn due to administrative reasons | Other (stated, no rule matched) |
| NCT02402036 | A Biomarker Study in Patients Getting Regorafenib for Metastatic Colorectal Cancer | Phase 2 | terminated | Mar 30, 2015 | Georgetown University | not stated | Not stated |
| NCT02205398 | Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and… | Phase 1 | terminated | Jul 31, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT02726334 | A Phase I, Dose Escalation Study of BNC101 in Patients With Metastatic Colorectal Cancer. | Phase 1 | terminated | Apr 1, 2016 | Bionomics Limited | Monotherapy arm completed. Combination arm did not proceed (sponsor decision). | Sponsor / business decision |
| NCT00651677 | Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer | N/A | withdrawn | Apr 3, 2008 | Weill Medical College of Cornell University | funding issues | Funding |
| NCT00611858 | Cetuximab, 5-FU and Radiation as Neoadjuvant Therapy for Patients With Locally Advanced… | Phase 2 | terminated | Feb 11, 2008 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT01925274 | A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS… | Phase 2 | terminated | Aug 19, 2013 | Pfizer | Enrollment to the study was terminated on 11Nvo2014 due to slow recruitment. There were no safety… | Safety / toxicity |
| NCT01523639 | A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage…(G-LUCAS) | Phase 2 | terminated | Feb 1, 2012 | Austrian Breast & Colorectal Cancer Study Group | Prematurely due to slow recruitment (07/08/2013). Newly defined study end=LPLV=05/11/2013. ABCSG… | Enrollment / accrual |
| NCT00267787 | Molecular Genetic and Pathological Studies of Anal Tumors | — | terminated | Dec 21, 2005 | Stanford University | not stated | Not stated |
| NCT01313026 | Treatment of "Low Anterior Resection Syndrome" by Percutaneous Nerve Evaluation and… | N/A | terminated | Mar 11, 2011 | University of Aarhus | Difficult to recruit participants | Enrollment / accrual |
| NCT00005030 | SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has… | Phase 1 | withdrawn | Jun 4, 2004 | M.D. Anderson Cancer Center | No enrollment. | Enrollment / accrual |
| NCT01740947 | Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer…(SELECT) | Phase 4 | terminated | Dec 4, 2012 | H. Jaap Bonjer, PhD | Superiority was no longer attainable | Other (stated, no rule matched) |
| NCT02669914 | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors | Phase 2 | terminated | Feb 1, 2016 | Washington University School of Medicine | Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice | Enrollment / accrual |
| NCT03527784 | Prestoma-Trial for Parastomal Hernia Prevention | N/A | terminated | May 17, 2018 | University of Oulu | Parastomal Parietex withdrawn from market by the manufacturer. | Drug supply |
| NCT03493009 | Optimizing the Preparation Regime Prior to Colonoscopy Procedure With Pure-Vu System | N/A | withdrawn | Apr 10, 2018 | Motus GI Medical Technologies Ltd | Difficulties to sign a contract with the hospital, due to logistic changes in the hospital. | Other (stated, no rule matched) |
| NCT00254436 | A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Weekly… | Phase 3 | terminated | Nov 16, 2005 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT03340558 | Atezolizumab Monotherapy vs Atezolizumab Plus Cobimetinib in Liver Metastases From…(ATELIER) | Phase 2 | withdrawn | Nov 13, 2017 | Niharika Mettu | Negative results in a similar study | Other (stated, no rule matched) |
| NCT03014284 | Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and… | — | withdrawn | Jan 9, 2017 | The University of Texas Health Science Center at San Antonio | Military collaborator sample supplier was transferred, no samples obtained | Other (stated, no rule matched) |
| NCT03232814 | Walk on: A Community-based Approach to Increase Physical Activity Among Men Treated for… | N/A | withdrawn | Jul 28, 2017 | University of Ottawa | No participants were recruited due to a lack of referrals. | Enrollment / accrual |
| NCT02650635 | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic,… | Phase 1 | terminated | Jan 8, 2016 | Mayo Clinic | permanently closed per sponsor's request | Other (stated, no rule matched) |
| NCT03096899 | A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for… | — | withdrawn | Mar 30, 2017 | The Rogosin Institute | The investigator conducting the study determined that the entry criteria for the proposed subjects… | Investigator |
| NCT02216149 | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow(FluoHeart) | Phase 2 | terminated | Aug 13, 2014 | Heikki Joensuu | Slow accrual | Enrollment / accrual |
| NCT03182894 | Epacadostat in Combination With Pembrolizumab and Azacitidine in Subjects With Metastatic… | Phase 1 / Phase 2 | withdrawn | Jun 9, 2017 | James J Lee | Study will not be conducted due to changes related to the investigational agent. | Other (stated, no rule matched) |
| NCT01286883 | Cancer Stem Cell Markers and Prognostic Markers in Circulating Tumor Cells | — | terminated | Jan 31, 2011 | Milton S. Hershey Medical Center | PI left Institution | Investigator |
| NCT02508077 | FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic… | Phase 2 | terminated | Jul 24, 2015 | City of Hope Medical Center | Poor Accrual | Enrollment / accrual |
| NCT02611661 | Local Ablative Strategies After Endovascular Radioembolization(LASER) | Phase 1 | terminated | Nov 23, 2015 | Washington University School of Medicine | Principal Investigator left the university. | Investigator |
| NCT01978249 | A Randomized, Prospective, Multicenter Study for the Role of Primary Tumor Resection in… | N/A | terminated | Nov 7, 2013 | Yonsei University | Because of the difficulties of participant enrollment. | Enrollment / accrual |
| NCT03111823 | Exercise Program During Chemotherapy in Metastatic Colorectal Cancer | N/A | terminated | Apr 13, 2017 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02654639 | Ph 2 Study of TAS-102 / Bevacizumab Maintenance Therapy Post Induction Chemotherapy in…(ALEXANDRIA) | Phase 2 | terminated | Jan 13, 2016 | Georgetown University | Principal investigator left the institution | Investigator |
| NCT01842971 | ALPPS (Liver Partition and Portal Vein Ligation) for Two-stage Hepatectomy for Colorectal… | Phase 3 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire, Amiens | Main reason: negative echo in the literature after the first publications. | Other (stated, no rule matched) |
| NCT00577109 | A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With… | Phase 2 | withdrawn | Dec 19, 2007 | Hoffmann-La Roche | Study was cancelled before patient enrollment | Enrollment / accrual |
| NCT03073473 | Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced Cancers | — | terminated | Mar 8, 2017 | Cota Inc. | Poor accrual | Enrollment / accrual |
| NCT00845039 | A Study of Irinotecan and Cetuximab With or Without IMC-A12 for Treatment of Participants…(FC-4) | Phase 2 | terminated | Feb 16, 2009 | Eli Lilly and Company | Study terminated early 22Feb2010 with only 4 participants due to business reasons. | Sponsor / business decision |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT02423954 | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)(NivoPlus) | Phase 1 / Phase 2 | terminated | Apr 22, 2015 | Western Regional Medical Center | Investigator no longer at site to enroll patients or write up data | Investigator |
| NCT03306966 | Assessing the Safety and Performance of the Endoscopic Linear Cutter Stapler and Reloads… | — | withdrawn | Oct 11, 2017 | Duomed | Design modification | Other (stated, no rule matched) |
| NCT00827580 | Eniluracil Hand Foot Syndrome | Phase 1 | terminated | Jan 23, 2009 | West Virginia University | not stated | Not stated |
| NCT00077233 | FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of… | Phase 3 | terminated | Feb 11, 2004 | Alliance for Clinical Trials in Oncology | Poor accrual | Enrollment / accrual |
| NCT01887509 | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to…(TRaMA) | N/A | terminated | Jun 27, 2013 | IHU Strasbourg | Difficulties with patients recruitment, study acceptance and protocol implementation. | Enrollment / accrual |
| NCT01926769 | A Phase II Study to Determine the Safety and Efficacy of Second-line Treatment With… | Phase 2 | terminated | Aug 21, 2013 | Gachon University Gil Medical Center | Slow accrual rate | Enrollment / accrual |
| NCT03253185 | A Study of SC-007 in Subjects With Advanced Cancer | Phase 1 | terminated | Aug 17, 2017 | AbbVie | Benefit/Risk Imbalance | Other (stated, no rule matched) |
| NCT00663819 | Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses | N/A | terminated | Apr 22, 2008 | W.L.Gore & Associates | Per SAP | Other (stated, no rule matched) |
| NCT02577588 | Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of…(ATACC) | Phase 1 | terminated | Oct 16, 2015 | National Center for Tumor Diseases, Heidelberg | not feasible | Other (stated, no rule matched) |
| NCT02503631 | Stool Sample Collection Protocol for Development of Screening Test for Colorectal Cancer… | — | terminated | Jul 21, 2015 | Exact Sciences Corporation | Changes in development plan | Other (stated, no rule matched) |
| NCT02638909 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal… | Phase 2 | terminated | Dec 23, 2015 | Criterium, Inc. | Lack of Enrollment | Enrollment / accrual |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 22, 2019source: clinicaltrials