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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01528345 | Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With… | Phase 2 | terminated | Feb 8, 2012 | Novartis Pharmaceuticals | Slow and low enrollment | Enrollment / accrual |
| NCT01346579 | Biomarkers in Tissue Samples From Older Women With Breast Cancer | — | terminated | May 3, 2011 | Alliance for Clinical Trials in Oncology | Study closed prematurely. | Other (stated, no rule matched) |
| NCT00933088 | Adolescent Daughters' Response and Adjustment to Maternal Breast Cancer | — | terminated | Jul 7, 2009 | NYU Langone Health | due to slow accrual and lack of funding | Enrollment / accrual |
| NCT01339000 | Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had… | Phase 2 | terminated | Apr 20, 2011 | National Cancer Institute (NCI) | Company supplying drug declared bankruptcy, thus there was no drug supply. | Drug supply |
| NCT00673829 | Trial of 2nd Generation Anti-CEA Designer T Cells in Metastatic Breast Cancer | Phase 1 | suspended | May 7, 2008 | Roger Williams Medical Center | Funding | Funding |
| NCT01805908 | Imaging With 111 Indium (111In)-Pertuzumab (PmAb) to Predict Response to Trastuzumab…(PETRA) | Phase 1 | terminated | Mar 6, 2013 | Ontario Clinical Oncology Group (OCOG) | Accrual is very poor | Enrollment / accrual |
| NCT00794989 | Flaxseed in Preventing Breast Cancer in Premenopausal Women at Risk of Developing Breast… | N/A | terminated | Nov 21, 2008 | Roswell Park Cancer Institute | low accrual | Enrollment / accrual |
| NCT02637375 | A Pilot Preoperative Trial of Ganetespib With Paclitaxel for Triple-Negative Breast Cancer | N/A | withdrawn | Dec 22, 2015 | University of Chicago | Study never opened (terminated as study drug no longer available) | Other (stated, no rule matched) |
| NCT02062983 | Early Predictor of Herceptin Cardio Toxicity in Breast Cancer Patients | — | suspended | Feb 14, 2014 | National Guard Health Affairs | Difficulty in enrolling patients | Enrollment / accrual |
| NCT00429403 | Goserelin Acetate Study for Ovarian Function in Patients With Primary Breast Cancer | Phase 3 | terminated | Jan 31, 2007 | M.D. Anderson Cancer Center | Study stopped due to low accrual. | Enrollment / accrual |
| NCT00567879 | A Trial of Panobinostat and Trastuzumab for Adult Female Patients With HER2 Positive… | Phase 1 / Phase 2 | terminated | Dec 5, 2007 | Novartis Pharmaceuticals | The study was terminated early due to insufficient evidence of clinical benefit. | Other (stated, no rule matched) |
| NCT01016028 | Chemotherapy-Induced Peripheral Neuropathy Survey | — | withdrawn | Nov 18, 2009 | M.D. Anderson Cancer Center | Study assessment tool development delayed. | Other (stated, no rule matched) |
| NCT02338531 | Biomarker Research Study for PF-03084014 in cHEmoresistant Triple-negative Breast cAncer(RHEA) | Phase 2 | withdrawn | Jan 14, 2015 | Jules Bordet Institute | Due to the discontinuation of the development of the Notch inhibitor PF-03084014-04 | Other (stated, no rule matched) |
| NCT01934114 | NIR Hypoxia Imaging of Breast Tumor Response to Neoadjuvant Chemotherapy in Vivo | — | terminated | Sep 4, 2013 | Dartmouth-Hitchcock Medical Center | not stated | Not stated |
| NCT02215876 | Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Eribulin Chemotherapy (ACE) in… | Phase 2 | withdrawn | Aug 13, 2014 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | No patients recruited. | Enrollment / accrual |
| NCT00346229 | Temperature-Sensitive Liposomal Doxorubicin and Hyperthermia in Treating Women With… | Phase 1 | terminated | Jun 29, 2006 | Duke University | Funding | Funding |
| NCT00131612 | An Investigation of the Effect of the Promoter Polymorphism in the… | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | did not apply for ethics renewal | Other (stated, no rule matched) |
| NCT00123812 | Frequency of Portal Images Required to Enhance Quality Assurance for Breast Cancer… | — | withdrawn | Jul 26, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01302002 | The Use of Metformin in Early Breast Cancer Patients Pre-Surgery | Early Phase 1 | withdrawn | Feb 23, 2011 | Instituto Nacional de Cancer, Brazil | not stated | Not stated |
| NCT00773474 | Lonafarnib in Metastatic Breast Cancer | Phase 2 | terminated | Oct 16, 2008 | George Sledge | funding terminated | Funding |
| NCT00020722 | Chemotherapy Followed by Peripheral Stem Cell Transplantation Plus Biological Therapy in… | Phase 2 | terminated | Jan 27, 2003 | Barbara Ann Karmanos Cancer Institute | Lack of funding to continue study. | Funding |
| NCT01410708 | TORI 104 Pre-Surgical Dasatinib | Phase 2 | withdrawn | Aug 5, 2011 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01593384 | Prospective Chart-Review: Impact of Combination - Digital Breast Tomosynthesis + Digital… | — | withdrawn | May 8, 2012 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01796977 | Using A Dissolved Oxygen Enriched Dressing in Nipple-sparing Mastectomy(NSM) | N/A | terminated | Feb 22, 2013 | Halyard Health | inability to enroll in this subject population | Enrollment / accrual |
| NCT01029925 | Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small… | Phase 2 | terminated | Dec 10, 2009 | Jonsson Comprehensive Cancer Center | DSMB determined, due to higher than expected risk/safety concerns, study should be closed. | Safety / toxicity |
| NCT01534455 | Efficacy and Tolerability of Eribulin Plus Lapatinib in Patients With Metastatic Breast… | Phase 2 | terminated | Feb 16, 2012 | GBG Forschungs GmbH | very slow patient recruitment and concerns about the actuality of the study design | Enrollment / accrual |
| NCT01773460 | Everolimus Beyond Progress for Patients Who Had Progress Under Everolimus and Exemestane(Evelyn) | Phase 3 | terminated | Jan 23, 2013 | GBG Forschungs GmbH | Study was stopped terminated early due to low recruitment. | Enrollment / accrual |
| NCT00573755 | Sorafenib and Letrozole, Anastrozole, or Exemestane in Treating Postmenopausal Women With… | Phase 2 | terminated | Dec 14, 2007 | Mayo Clinic | lack of participant accrual | Enrollment / accrual |
| NCT00998738 | Calcium and Magnesium in Preventing Peripheral Neuropathy Caused by Ixabepilone in… | Phase 3 | terminated | Oct 20, 2009 | Mayo Clinic | lack of accrual | Enrollment / accrual |
| NCT01890824 | Fat Metabolism Following Chemotherapy in Breast Cancer | — | terminated | Jul 2, 2013 | Texas A&M University | not stated | Not stated |
| NCT02131506 | A Study of Lapatinib in Combination With Caelyx in Patients With Advanced HER2 Positive…(CAELYX) | Phase 1 | terminated | May 6, 2014 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | Safety reasons | Safety / toxicity |
| NCT00580021 | Clinical Outcomes in Hereditary Cancer | — | withdrawn | Dec 24, 2007 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT02539615 | A Trial of the ForeCYTE Breast Aspirator for Cytological Testing of Nipple Aspirate Fluid… | Phase 3 | withdrawn | Sep 3, 2015 | Atossa Therapeutics, Inc. | not stated | Not stated |
| NCT00824733 | Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic… | Phase 2 | terminated | Jan 19, 2009 | Bhuvaneswari Ramaswamy | Inaccurate patient accrual for trial | Enrollment / accrual |
| NCT01985893 | Safety and Efficacy of Lapatinib Plus Trastuzumab or Lapatinib Plus Capecitabine in…(THOR) | Phase 2 | withdrawn | Nov 15, 2013 | Berufsverband Niedergelassener Gynäkologischer Onkologen in Deutschland e.V. | Due to missing patient recruitment, the financial support was stopped. | Enrollment / accrual |
| NCT00595023 | GeneSearch Breast Lymph Node (BLN) Assay Timing Study | — | terminated | Jan 16, 2008 | Janssen Diagnostics, LLC | GeneSearch™ BLN Assay has been voluntarily withdrawn from the US market. | Other (stated, no rule matched) |
| NCT00595296 | GeneSearch™ Breast Lymph Node (BLN) Assay Post Approval Study | — | terminated | Jan 16, 2008 | Janssen Diagnostics, LLC | GeneSearch™ BLN Assay has been voluntarily withdrawn from the US market. | Other (stated, no rule matched) |
| NCT00978276 | Immunohistochemical (IHC) Scoring for Receptors Expression in Breast Tissues | — | withdrawn | Sep 16, 2009 | Applied Spectral Imaging Ltd. | Personal changes in the company | Sponsor / business decision |
| NCT02252991 | Adaptated Physical Activity in Cancerology(APACAN) | N/A | terminated | Sep 30, 2014 | Centre Jean Perrin | Difficulty to include patients | Other (stated, no rule matched) |
| NCT00305643 | Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast… | Phase 3 | terminated | Mar 22, 2006 | M.D. Anderson Cancer Center | Terminated due to low accrual. No data analyzed. | Enrollment / accrual |
| NCT01249157 | Histologic Assessment of the Difference Between 18F-2-fluoro-2-deoxy_D-glucose Positron… | N/A | terminated | Nov 29, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01532232 | Tobacco Dependence in Breast Cancer Patients Trial of Varenicline (Chantix) | — | terminated | Feb 14, 2012 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00347438 | Capecitabine as NeoAdjuvant Therapy in Locally Advanced Breast Cancer | Phase 2 | terminated | Jul 4, 2006 | University of Chicago | a result of slow accrual | Enrollment / accrual |
| NCT00343759 | Presurgical Therapy With Lapatinib to Explore Molecular Determinants of Response to… | Phase 2 | withdrawn | Jun 23, 2006 | University of Pennsylvania | not stated | Not stated |
| NCT00636441 | Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in… | Phase 2 | terminated | Mar 14, 2008 | Duke University | Study terminated due to reproducibility issues with genomics prediction model | Other (stated, no rule matched) |
| NCT02004496 | Randomized Controlled Single-blind Trial to Evaluate the Mobile Tracking of Symptoms in…(PatAPP1) | N/A | terminated | Dec 9, 2013 | University of Zurich | Termination due to relevant update of the operation system. Adaption of the application was not… | Other (stated, no rule matched) |
| NCT00216047 | PTK787 + Trastuzumab for HER2 Overexpressing Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | Low patient enrollment; toxicities | Safety / toxicity |
| NCT00235235 | A Correlative Study for Predicting Response and Toxicity in Patients Receiving… | — | terminated | Oct 10, 2005 | Hoosier Cancer Research Network | Funding terminated | Funding |
| NCT01391039 | Diagnostic Study of Early Breast Cancer Using Ultrasound | N/A | terminated | Jul 11, 2011 | Sunnybrook Health Sciences Centre | Low recruitment | Enrollment / accrual |
| NCT01954706 | Exercise to Prevent Aromatase Inhibitor Side Effects in Breast Cancer Patients(BCS2) | N/A | terminated | Oct 7, 2013 | Baltimore VA Medical Center | The study was stopped due to recruitment difficulties | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jul 11, 2016source: clinicaltrials