Clinical trial · Observational
Fat Metabolism Following Chemotherapy in Breast Cancer
The Effect of Chemotherapy on Fat Metabolism and Digestion and Function in Breast Cancer Patients.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Following chemotherapy, breast cancer patients primarily gain fat mass and lose muscle mass. Both depletion of muscle and an increase of fat mass in breast cancer patients are related to short survival, and decreased skeletal muscle mass and function may result in fatigue and inactivity, which contributes to fat mass changes and can be responsible for chemo-toxicity and increased mortality. The purpose of this study is to provide detailed insight in chemotherapy related changes in lipid metabolism and gut digestion and absorption of fat in breast cancer patients compared to matched healthy controls. This will provide required information that is necessary to implement new strategies to develop optimal nutritional regimen in breast cancer patients. The hypothesis is that chemotherapy in breast cancer is related to altered gut function and absorption and to increases in fat synthesis that lead to fat accumulation. In addition, we will examine the effect of cancer, chemotherapy, and gender by comparing fat digestion/absorption and fat metabolism of the breast cancer before and after chemotherapy, to aged matched healthy female and male controls.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Breast Cancer Patients
- description
- Breast cancer patients to be studied before and after chemotherapy
- label
- Healthy Female Controls
- description
- Healthy female controls will be compared to breast cancer patients before and after chemotherapy and to healthy male controls
- label
- Healthy Male Controls
- description
- Healthy male controls will be compared to healthy female controls to determine gender differences
Primary outcomes (2)
- measure
- Hepatic triglyceride synthesis
- timeFrame
- Pre meal ingestion and 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270, and 300 min post meal ingestion
- description
- changes in hepatic triglyceride synthesis before and after a meal
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion criteria cancer subjects: * Diagnosed with breast cancer * Scheduled for chemotherapy * Ability to sign informed consent * Age 30 years and older * Ability to lie in supine position for 7 hours Inclusion criteria healthy subjects: * Healthy male \& female according to the investigator's or appointed staff's judgment * Age 30 years or older * No diagnosis of cancer Exclusion Criteria: * Presence of fever within the last 3 days * Untreated metabolic diseases including hepatic or renal disorder * Presence of acute illness or metabolically unstable chronic illness * Use of nutritional supplements within 5 days of first test day * Any other condition according to the PI or nurse that would interfere with the study or safety of the patient * Failure to give informed consent * Possible) pregnancy
References
Publications (1)
- DERIVEDHuttl VN, Deutz N, Wierzchowska-McNew RA, Ruebush LE, Engelen M. Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex. Am J Hypertens. 2026 May 18:hpag047. doi: 10.1093/ajh/hpag047. Online ahead of print. PMID 42149813