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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
200 stopped studies mapped to Malignant Anorectal Neoplasm and descendants · 93% state a reason
Over the 200 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02266849 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded… | Phase 3 | terminated | Oct 17, 2014 | Odense University Hospital | Insuficcient recruiting | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | N/A | withdrawn | Apr 11, 2014 | University of Virginia | No accrual. New study opening with modified technique. | Enrollment / accrual |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT00767234 | Permission to Collect Blood Over Time for Research | — | terminated | Oct 7, 2008 | Stanford University | Accrual issues - Low Accrual | Enrollment / accrual |
| NCT00216086 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in… | Phase 2 | terminated | Sep 22, 2005 | Gabi Chiorean, MD | Funding withdrawn | Funding |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT01843452 | Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine,… | Phase 2 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire Vaudois | Poor recruitment | Enrollment / accrual |
| NCT00973193 | Preoperative Panitumumab and Radiotherapy in Rectal Cancer(PrePaRad) | Phase 2 | terminated | Sep 9, 2009 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | The intermediate analyses did not allowed to continue the clinical study. | Other (stated, no rule matched) |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00250835 | Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for… | Phase 2 | terminated | Nov 8, 2005 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT02162641 | Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer(R-SeNSAR) | — | withdrawn | Jun 13, 2014 | The Christie NHS Foundation Trust | The study was terminated early as it failed to recruit. | Enrollment / accrual |
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | No enrollment | Enrollment / accrual |
| NCT01717014 | Radial Reload Open LAR Case Series | N/A | terminated | Oct 30, 2012 | Medtronic - MITG | not stated | Not stated |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX…(HDRBT) | Phase 2 | withdrawn | Aug 7, 2012 | Beth Israel Medical Center | No participants were enrolled | Enrollment / accrual |
| NCT01544452 | Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in… | N/A | terminated | Mar 6, 2012 | Herlev Hospital | Lack of MR scanning capacity | Other (stated, no rule matched) |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT01257035 | Predictive Value of 18F-FAZA in Rectum Cancer(FAZA) | — | terminated | Dec 9, 2010 | Vejle Hospital | The logistics of this trial (incl. supply of tracer) in connection with the patients' treatment… | Drug supply |
| NCT01872104 | Safety and Efficiency of Photodynamic Therapy for Rectal Cancer(PDT-R-01) | Phase 2 / Phase 3 | suspended | Jun 7, 2013 | li xiong | Modifying the clinnicaltrials | Other (stated, no rule matched) |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070265 | Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With… | Phase 2 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00068744 | Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients… | Phase 2 / Phase 3 | terminated | Sep 11, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT01031056 | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers | — | withdrawn | Dec 14, 2009 | Stanford University | Change in research focus | Other (stated, no rule matched) |
| NCT01196000 | Laparoscopic Surgery or Robotic-Assisted Laparoscopic Surgery in Treating Patients With… | N/A | withdrawn | Sep 8, 2010 | City of Hope Medical Center | The study has never been opened to accrual at COH. Study to be closed at COH due to the lack of… | Enrollment / accrual |
| NCT00503932 | Proton Therapy With Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Jul 19, 2007 | M.D. Anderson Cancer Center | No participant enrollment. | Enrollment / accrual |
| NCT01126450 | Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer | Phase 1 | terminated | May 19, 2010 | Case Comprehensive Cancer Center | low accrual,loss of funding and results from EU study showing drug ineffective. | Enrollment / accrual |
| NCT00532987 | Assessment of Health Related Quality of Life in Patients Treated for Rectal Cancer | — | terminated | Sep 21, 2007 | Stanford University | not stated | Not stated |
| NCT00394615 | Metabolic Imaging Predict Histopathologic Response to Preop ChemoXRT for Locally Advanced… | N/A | terminated | Nov 1, 2006 | Stanford University | Protocol approval expired | Other (stated, no rule matched) |
| NCT00677287 | Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00677612 | Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00399009 | Comparative Study of Circular Stapling Instruments | N/A | terminated | Nov 14, 2006 | Uppsala University Hospital | One of the instruments in the study was withdrawn from the market before the calculated number of… | Other (stated, no rule matched) |
| NCT00457327 | Pilot Study for Evaluation of the Need for Protective Ileostomy After Low Anterior… | Phase 2 | terminated | Apr 6, 2007 | Heidelberg University | RCT with same hypothesis ended and showed a superiority for protective ileostomy after lower… | Other (stated, no rule matched) |
| NCT00176787 | Radiation Therapy With Capecitabine in Rectal Cancer | Phase 2 | terminated | Sep 15, 2005 | University of Michigan Rogel Cancer Center | recruitment goals met | Enrollment / accrual |
| NCT00346099 | Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With… | Phase 2 | withdrawn | Jun 29, 2006 | NSABP Foundation Inc | Protocol closed based on new (and as yet unpublished) information from a phase II clinical trial. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 11, 2016source: clinicaltrials