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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
367 stopped studies mapped to Head and Neck Carcinoma and descendants · 94% state a reason
Over the 367 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02831179 | Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and… | Phase 1 | withdrawn | Jul 13, 2016 | Vanderbilt-Ingram Cancer Center | Loss of funding support | Funding |
| NCT02211027 | Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA | Phase 1 | withdrawn | Aug 7, 2014 | Robert Ferris | not stated | Not stated |
| NCT02538627 | Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib | Phase 1 | terminated | Sep 2, 2015 | Merrimack Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT00257335 | Intensity-Modulated Radiotherapy for Recurrent Head and Neck Cancer | Phase 2 | withdrawn | Nov 22, 2005 | Nilam Ramsinghani | Due to no patient enrollment this study was withdrawn/closed | Enrollment / accrual |
| NCT01303237 | A Post Marketing Surveillance Study to Assess the Safety and Efficacy of Cetuximab Plus…(PMS LAD SCCHN) | — | terminated | Feb 24, 2011 | Merck KGaA, Darmstadt, Germany | The study was discontinued due to slow recruitment and subjects not completing follow up period. | Enrollment / accrual |
| NCT02593929 | Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and… | Early Phase 1 | withdrawn | Nov 2, 2015 | University of Pittsburgh | not stated | Not stated |
| NCT00895245 | Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing… | Phase 2 | terminated | May 8, 2009 | University of Washington | Study stopped due to lack of efficacy in first 6 patients | Efficacy / futility |
| NCT02196168 | Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or… | Phase 2 | terminated | Jul 21, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01267240 | Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head… | Phase 2 | terminated | Dec 28, 2010 | National Cancer Institute (NCI) | Study treatment did not show clinical activity. | Other (stated, no rule matched) |
| NCT00392665 | Bevacizumab/Tarceva and Tarceva/Sulindac in Squamous Cell Carcinoma of the Head and Neck | Phase 2 | terminated | Oct 26, 2006 | Massachusetts General Hospital | slow accrual | Enrollment / accrual |
| NCT01865838 | A Study Into the Effect of Seprafilm in Open Total Thyroidectomy | N/A | terminated | May 31, 2013 | National Cancer Centre, Singapore | safety issue | Safety / toxicity |
| NCT00903461 | Safety and Efficacy of Radiation/Cetuximab Plus EGFR Antisense DNA for Head and Neck… | Phase 1 | terminated | May 18, 2009 | University of Pittsburgh | drug supply issues | Drug supply |
| NCT00797290 | Photon/Proton Radiation Therapy for Carcinoma of the Nasopharynx(NP01) | — | terminated | Nov 25, 2008 | University of Florida | Slow enrollment, Feasibility issues | Enrollment / accrual |
| NCT02331875 | Efficacy Study of Pre-operative IPH2201 in Patients With Squamous Cell Carcinoma of the… | Phase 1 / Phase 2 | terminated | Jan 6, 2015 | Innate Pharma | lack of recruitment | Enrollment / accrual |
| NCT01507467 | IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell…(IAEA-HypoX) | Phase 3 | terminated | Jan 11, 2012 | Danish Head and Neck Cancer Group | Insufficient recruitment | Enrollment / accrual |
| NCT01283178 | Phase I Study of IMRT and Molecular-Image Guided Adaptive Radiation Therapy for Advanced… | Phase 1 | terminated | Jan 25, 2011 | Virginia Commonwealth University | The study was terminated. The data analysis was futile with only 3 accruals. PI opted to terminate… | Enrollment / accrual |
| NCT02649530 | A Phase II Trial Evaluating WNT974 in Patients With Metastatic Head and Neck Squamous… | Phase 2 | withdrawn | Jan 7, 2016 | University of Michigan Rogel Cancer Center | funding withdrawn | Funding |
| NCT01975688 | A Pharmacokinetic Study of Single Doses of Sativex in Treatment-induced Mucositis | Phase 1 | terminated | Nov 5, 2013 | GW Pharmaceuticals Ltd | Slow recruitment | Enrollment / accrual |
| NCT01820312 | A Phase II Study to Evaluate Low-Dose Fractionated Radiotherapy (LDFRT) | Phase 2 | withdrawn | Mar 28, 2013 | University of Arkansas | Due to no enrollment. | Enrollment / accrual |
| NCT01528137 | Talactoferrin in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer… | Phase 1 | terminated | Feb 7, 2012 | Stanford University | Negative data from another trial led to termination of this trial by sponsor. | Other (stated, no rule matched) |
| NCT02334319 | Ganetespib Window of Opportunity Study in Head and Neck Cancers | Phase 1 | terminated | Jan 8, 2015 | Emory University | Lack of funding | Funding |
| NCT00627835 | Dose Escalation Trial of Neoadjuvant Sorafenib and Concurrent Sorafenib, Cisplatin and… | Phase 1 | withdrawn | Mar 3, 2008 | British Columbia Cancer Agency | Site decided not to open this study | Other (stated, no rule matched) |
| NCT00377247 | Active Immunization of Patients With Carcinoma of Oral Cavity or Oropharynx With… | Phase 1 | terminated | Sep 18, 2006 | University of Pittsburgh | study closed to accrual due to slow accrual | Enrollment / accrual |
| NCT02119728 | Photodynamic Therapy With HPPH in Treating Patients With Squamous Cell Carcinoma of the… | Phase 2 | withdrawn | Apr 22, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02143622 | Study of Efficacy and Safety of LJM716 and Cetuximab in Head and Neck Squamous Cell… | Phase 1 / Phase 2 | withdrawn | May 21, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT02479178 | A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical…(iNSITE2) | Phase 2 | terminated | Jun 24, 2015 | BIND Therapeutics | not stated | Not stated |
| NCT01285635 | A Study of AT-101 in Combination With Docetaxel in Squamous Cell Carcinoma Of The Head… | Phase 2 | terminated | Jan 28, 2011 | University of Michigan Rogel Cancer Center | drug is no longer manufactured | Drug supply |
| NCT02516774 | A Trial of Adalimumab Combined to Chemotherapy and Radiotherapy in Patients With…(TAM-RT) | Phase 1 | withdrawn | Aug 6, 2015 | Gustave Roussy, Cancer Campus, Grand Paris | No patients enrolled | Enrollment / accrual |
| NCT00984217 | Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies | Phase 2 | withdrawn | Sep 25, 2009 | University of Pittsburgh | Decided not to pursue at UPCI | Other (stated, no rule matched) |
| NCT00272181 | Study of Proxinium for Treating Patients With Squamous Cell Head and Neck Cancer | Phase 2 | terminated | Jan 4, 2006 | Sesen Bio, Inc. | Slow accrual in North America | Enrollment / accrual |
| NCT01586182 | Stereotactic Boost for Oropharyngeal Squamous Cell Carcinoma | Phase 1 / Phase 2 | withdrawn | Apr 26, 2012 | Dana-Farber Cancer Institute | Local IRB closed the study due to poor accural. | Other (stated, no rule matched) |
| NCT01949740 | Patient Preferences in Making Treatment Decisions in Patients With Stage I-IVA… | — | terminated | Sep 24, 2013 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT02058017 | OPB-51602 in Locally Advanced Nasopharyngeal Carcinoma Prior to Definitive… | Phase 1 | terminated | Feb 7, 2014 | National University Hospital, Singapore | Lactic and metabolic acidosis of OPB-51602 is not tolerable | Other (stated, no rule matched) |
| NCT01694576 | NPC Staged N2-3M0:Adjuvant Chemotherapy or Just Observation After Concurrent… | Phase 2 | terminated | Sep 27, 2012 | Jiangsu Cancer Institute & Hospital | slow patient enrollment | Enrollment / accrual |
| NCT02156180 | Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma | — | suspended | Jun 5, 2014 | Queensland Centre of Excellence for Head and Neck Cancer | Awaiting funding to facilitate selected-ion flow-tube mass spectrometry (SIFT/MS) | Funding |
| NCT01953952 | Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage… | Phase 2 | withdrawn | Oct 1, 2013 | Radiation Therapy Oncology Group | Slow accrual | Enrollment / accrual |
| NCT01133262 | Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET)… | — | withdrawn | May 28, 2010 | Washington University School of Medicine | Feasibility/pilot study of 5 subjects registration not required | Other (stated, no rule matched) |
| NCT01254734 | Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck… | N/A | terminated | Dec 7, 2010 | City of Hope Medical Center | The study will be rewritten as a data registry study | Other (stated, no rule matched) |
| NCT01718223 | Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent… | N/A | withdrawn | Oct 31, 2012 | Roswell Park Cancer Institute | implementation issues | Other (stated, no rule matched) |
| NCT01305772 | Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated…(TOP0901) | Phase 2 | terminated | Mar 1, 2011 | Neal Ready | This study was terminated for low accrual. | Enrollment / accrual |
| NCT01682031 | Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck… | Phase 2 | terminated | Sep 10, 2012 | Roswell Park Cancer Institute | Due to a lack of funding | Funding |
| NCT01403259 | SOX as Salvage Treatment in Nasopharyngeal Carcinoma | Phase 2 | terminated | Jul 27, 2011 | Fudan University | poor accrual of eligible patients | Enrollment / accrual |
| NCT00911326 | Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma | Phase 3 | terminated | Jun 1, 2009 | Navidea Biopharmaceuticals | The trial was terminated early based on an interim review by the Data and Safety Monitoring… | Safety / toxicity |
| NCT01360827 | EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic… | Phase 1 | terminated | May 26, 2011 | Merck KGaA, Darmstadt, Germany | Study terminated due to potential safety concerns in combination with platinum-based therapies | Safety / toxicity |
| NCT00507429 | Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid…(FACT) | Phase 2 / Phase 3 | terminated | Jul 26, 2007 | Mateon Therapeutics | Low rate of subject accrual | Enrollment / accrual |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00184028 | Combination of Taxotere and Oxaliplatin in Squamous Cell Carcinoma of the Head and Neck | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT01701349 | Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid…(FACT2) | Phase 3 | withdrawn | Oct 5, 2012 | Mateon Therapeutics | Expected inability to recruit study participants in a reasonable amount of time. | Enrollment / accrual |
| NCT00095693 | Sorafenib Tosylate in Treating Patients With Locally Advanced, Metastatic, or Locally… | Phase 2 | terminated | Nov 8, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 28, 2017source: clinicaltrials