Publication
Somatic in frame deletions not involving juxtamembranous cysteine residues strongly activate the RET proto-oncogene.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Neoplasmcivic_curation1.00
- geneRETcivic_curation1.00
- variantRET C634Rcivic_curation1.00
- variantRET E632_L633delcivic_curation1.00
- variantRET M918Tcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 9191060
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RET C634R1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11874In a colony formation assay with NIH3T3 cells, RET C634R was used as a positive control (called MEN2A after its association with that disease). Cells transformed with C634R showed significant colony f… (full text at CIViC) PMID 9191060 · Ceccherini et al., 1997 · Open in CIViC | civic |
| RET E632_L633del1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11873A RET c.1894_1899del p.E632_L633del mutation was identified in a 32-year-old patient with a particularly aggressive medullary thyroid cancer. This mutation removes 2 amino acids adjacent to the cyste… (full text at CIViC) PMID 9191060 · Ceccherini et al., 1997 · Open in CIViC | civic |
| RET M918T1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID12709Two novel somatic interstitial in-frame deletions in RET, with unknown transformation potential, were identified in medullary thyroid carcinoma (MTC) tumor samples. One of these (RET E632_L633del) was… (full text at CIViC) PMID 9191060 · Ceccherini et al., 1997 · Open in CIViC | civic |