Publication
Mutational processes shape the landscape of TP53 mutations in human cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 16, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260916-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneTP53civic_curation1.00
- variantTP53 Y126Ccivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-26
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30224644
- Run
- ING-CIVIC-20260926-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 F134S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | submitted | EID13308In pooled TP53 saturation-mutagenesis screens in TP53-null A549 lung carcinoma cells, TP53 F134S showed enrichment following nutlin-3 treatment (mean Z-score 1.192) and depletion following etoposide t… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC | civic |
| TP53 P278A2 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | submitted | EID8082Isogenic WT TP53 (p53WT) and null TP53 (p53NULL) A549 human lung carcinoma cell lines were induced with WT, P278A and luciferase, and treated with Nutlin-3 to inhibit MDM2 function, releasing p53 acti… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC | civic |
| 〃 | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID8083Isogenic WT TP53 (p53WT) and null TP53 (p53NULL) A549 human lung carcinoma cell lines were induced with WT, P278A and luciferase, and treated with Nutlin-3 to inhibit MDM2 function, releasing p53 acti… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC | civic |
| TP53 Y126C2 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID13259In pooled saturation-mutagenesis screens using TP53-null A549 lung carcinoma cells, TP53 Y126C showed behavior consistent with loss of p53 function. Y126C had a Z-score of 1.11 under nutlin-3 selectio… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC | civic |
| 〃 | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID13260In TP53-WT A549 cells (human lung adenocarcinoma cell line) expressing a pooled TP53 mutant library, TP53 Y126C was enriched during nutlin-3 selection with a Z-score of 1.40, consistent with interfere… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC | civic |