TP53 P278A

CI-VAR-00003326Explore in graph →ClinVar 376645 CIViC 3005 rs17849781

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease3unmapped disease
TP53 P278A	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID8082 Isogenic WT TP53 (p53WT) and null TP53 (p53NULL) A549 human lung carcinoma cell lines were induced with WT, P278A and luciferase, and treated with Nutlin-3 to inhibit MDM2 function, releasing p53 acti… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC	civic
TP53 P278A	(functional)	Functional	D	Supports Dominant Negative	3	submitted	EID8083 Isogenic WT TP53 (p53WT) and null TP53 (p53NULL) A549 human lung carcinoma cell lines were induced with WT, P278A and luciferase, and treated with Nutlin-3 to inhibit MDM2 function, releasing p53 acti… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376645	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Ovarian neoplasm; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Li-Fraumeni syndrome 1	germline/somatic	6	May 26, 2025	clinvar