Gene

STAG3

STAG3 cohesin complex component

Explore in graph →CI-GENE-00033986HGNC:11356 ENSG00000066923 NCBI 10734 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAG3 Underexpression1
Vemurafenib	Melanoma	Predictive	D	Supports Resistance	4	accepted	EID1660 A375 melanoma cells containing an inducible shRNA for STAG3 were grown as xenograft tumors in nude mice. The mice in which STAG3 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC) PMID 27500726 · Shen et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (4)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	10	103	9.7%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
· Nat Med · 2016 · PMID 27500726 · validated civic_curation pubmed