Publication
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMalignant Neoplasmcivic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR3 V555Mcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26097890
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR3 V555M2 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Does Not Support Oncogenicity | 4 | accepted | EID12990NIH3T3 cells stably expressing FGFR3 V555M did not exhibit increased cell proliferation, anchorage-independent growth, or morphological transformation compared with cells expressing wild-type FGFR3, w… (full text at CIViC) PMID 26097890 · Bunney et al., 2015 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 4 | accepted | EID12989Purified recombinant FGFR3 kinase domain protein harboring the V555M gatekeeper substitution exhibited increased in vitro kinase activity toward a peptide substrate and increased catalytic efficiency … (full text at CIViC) PMID 26097890 · Bunney et al., 2015 · Open in CIViC | civic |