FGFR3 V555M

CI-VAR-00004540Explore in graph →NP_000133.1:p.Val555MetNM_022965.4:c.1327G>AClinVar 2203501 CIViC 2400

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 4 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm2
FGFR3 V555M	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID12882 In a saturation mutagenesis study, all possible point mutations in the FGFR 1-4 kinase domain (amino acids 472-807 for FGFR3) were tested. Lentiviral plasmids were infected at MOI < 0.3 into the growt… (full text at CIViC) PMID 41361008 · Tangermann et al., 2025 · Open in CIViC	civic
FGFR3 V555M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	4	accepted	EID12990 NIH3T3 cells stably expressing FGFR3 V555M did not exhibit increased cell proliferation, anchorage-independent growth, or morphological transformation compared with cells expressing wild-type FGFR3, w… (full text at CIViC) PMID 26097890 · Bunney et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Transitional Cell Carcinoma1
FGFR3 V555M	Infigratinib	Predictive	C	Supports Resistance	3	submitted	EID6406 In this one-arm study, 67 patients with metastastic urothelial carcinoma and diverse FGFR3 alterations were treated with pan-FGFR Inhibitor BGJ398. The majority of patients (70.1%) had received two or… (full text at CIViC) PMID 29848605 · Pal et al., 2018 · Open in CIViC	civic

Unmapped disease2unmapped disease
FGFR3 V555M	(functional)	Functional	D	Supports Gain Of Function	4	accepted	EID12988 Purified recombinant FGFR3 kinase domain protein harboring the V555M substitution exhibited increased in vitro kinase activity compared with wild-type FGFR3. Both autophosphorylation and peptide subst… (full text at CIViC) PMID 26992226 · Patani et al., 2016 · Open in CIViC	civic
FGFR3 V555M	(functional)	Functional	D	Supports Gain Of Function	4	accepted	EID12989 Purified recombinant FGFR3 kinase domain protein harboring the V555M gatekeeper substitution exhibited increased in vitro kinase activity toward a peptide substrate and increased catalytic efficiency … (full text at CIViC) PMID 26097890 · Bunney et al., 2015 · Open in CIViC	civic