Publication
Identifying the determinants of response to MDM2 inhibition.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (20)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 20
- cancerMalignant Neoplasmcivic_curation1.00
- drugMDM2 Inhibitor AMGMDS3civic_curation1.00
- geneTP53civic_curation1.00
- variantTP53 Deleterious Mutationcivic_curation1.00
- variantTP53 G245Scivic_curation1.00
- variantTP53 M237Icivic_curation1.00
- variantTP53 R158Hcivic_curation1.00
- variantTP53 R158Lcivic_curation1.00
- variantTP53 R175Hcivic_curation1.00
- variantTP53 R248Qcivic_curation1.00
- variantTP53 R248Wcivic_curation1.00
- variantTP53 R249Scivic_curation1.00
- variantTP53 R273Ccivic_curation1.00
- variantTP53 R273Hcivic_curation1.00
- variantTP53 R280Kcivic_curation1.00
- variantTP53 R280Tcivic_curation1.00
- variantTP53 T125Tcivic_curation1.00
- variantTP53 V157Fcivic_curation1.00
- variantTP53 Wildtypecivic_curation1.00
- variantTP53 Y220Ccivic_curation1.00
Curated evidence
Evidence citing this paper (24)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25730903
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 C135F1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10076A subset of 58 cancer cell lines with unaltered TP53 are sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 inhibitor.… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 C135fs1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10073Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 Deleterious Mutation1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID2967MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows that only cancer cell lines with unaltered TP53 may be sensitive to MDM2 Inhibitor AMGMDS3, while th… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 G244R1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10072Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 G245S1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4883Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 H193R1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10063Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 I251T1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10075Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 K132Q1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | submitted | EID10065Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 M237I1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID4885Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R158H1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID4886Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R158L1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID4891Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R175H2 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID4880Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| 〃 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID10074Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R248Q1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID3042Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R248W1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4879Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R249S1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4888Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R273C1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4881Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R273H1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4882Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R280K1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4889Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 R280T1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4890Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 V157F1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4887Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 Wildtype1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID2964MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows that only cancer cell lines with unaltered TP53 may be sensitive to MDM2 Inhibitor. PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 Y220C1 | ||||||||
| MDM2 Inhibitor AMGMDS3 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 4 | accepted | EID4884Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |
| TP53 T125T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 4 | accepted | EID10059TP53 mutant cell lines were treated with an MDM2 inhibitor (AMG 232) and expression of TP53, MDM2 and p21 were measured by immunoblot. Lack of upregulation was seen in all TP53 mutant (G>A transversio… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC | civic |