TCGA, Cell 2013 — PMID 24120142

Abstract

Abstract (excerpt)

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Linked entities

Linked entities (1)

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Validated 1

cancerDiffuse Gliomacbioportal_study1.00

Curated evidence

Evidence citing this paper (3)

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EGFR Amplification + SEPTIN14 FusionSEPTIN14 EGFR1
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	2	submitted	EID11151 Seminal paper presenting the original analysis of the TCGA Glioblastoma dataset, of over 500 glioblastoma genomes. EFGR::SEPT14 fusion was found in 6 cases by WGS and confirmed by RNASeq. The fusion i… (full text at CIViC) PMID 24120142 · Brennan et al., 2013 · Open in CIViC	civic
EGFR Fusion1
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	1	submitted	EID10934 SEC61G::EGFR fusion identified in 4 out of 164 (2.4%) glioblastoma tumors (TCGA GBM working group, patient samples with pathobiology data). Fusion transcripts were confirmed by RNA-seq and were freque… (full text at CIViC) PMID 24120142 · Brennan et al., 2013 · Open in CIViC	civic
VOPP1 Fusion1
(oncogenic)	GlioblastomaCURATED_BROADER	Oncogenic	C	Supports Oncogenicity	1	submitted	EID12552 Exome DNA sequencing was performed in 291 glioblastomas, 42 with whole genome sequencing, to update the TCGA dataset. Whole Genome Sequencing was performed on 42 of the samples, and ten of these demo… (full text at CIViC) PMID 24120142 · Brennan et al., 2013 · Open in CIViC	civic