VOPP1 Fusion

CI-VAR-00001482Explore in graph →CIViC 5245

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma1
EGFR::VOPP1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID12552 Exome DNA sequencing was performed in 291 glioblastomas, 42 with whole genome sequencing, to update the TCGA dataset. Whole Genome Sequencing was performed on 42 of the samples, and ten of these demo… (full text at CIViC) PMID 24120142 · Brennan et al., 2013 · Open in CIViC	civic
Solid Neoplasm1
EGFR::VOPP1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID12550 Next generation sequencing was performed on 35023 Chinese cases with 13 different solid tumor types. EGFR Fusions were detected in 106 samples. All EGFR fusions contained the complete tyrosine kinase … (full text at CIViC) PMID 39054543 · Zhang et al., 2024 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.