Publication
Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneTP53civic_curation1.00
- variantTP53 C238Ycivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21343334
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 C238Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID7215This study evaluated the dominant negative potential of 103 p53 germline mutations contained in the IRAC database. The C238Y variant was considered severely deficient as cotransformation with empty ve… (full text at CIViC) PMID 21343334 · Monti et al., 2011 · Open in CIViC | civic |
| TP53 G105C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | submitted | EID13195In yeast luciferase reporter assays evaluating four p53 response elements, germline TP53 G105C retained 25%, 22%, 22%, and 86% of wild-type transactivation activity at the MDM2, BAX, PUMA, and P21 rep… (full text at CIViC) PMID 21343334 · Monti et al., 2011 · Open in CIViC | civic |