Publication
Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- geneTP53civic_curation1.00
- variantTP53 C242Fcivic_curation1.00
- variantTP53 C242Scivic_curation1.00
- variantTP53 C242Ycivic_curation1.00
- variantTP53 E285Kcivic_curation1.00
- variantTP53 G154Scivic_curation1.00
Curated evidence
Evidence citing this paper (50)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20407015
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 A138V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Unaltered Function | 2 | submitted | EID9492Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C135F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9440Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C135Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9441Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C141W1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9500Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C176F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9443Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C238F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9448Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C242F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9451Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C242S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9452Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 C242Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9453Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 D259V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9462Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 D281E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9466Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 E285K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Unaltered Function | 2 | accepted | EID9496Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 G154S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9502Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 G244V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9455Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 G245S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9456Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 G266R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9463Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 H179R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9444Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 H214R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 1 | submitted | EID11082Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 K305M1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9467Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 L130V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9499Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 L194P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9505Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 L194R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9447Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 M237I1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9507Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 M243T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9454Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 M246A1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9457Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 M246T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9458Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 N239D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9449Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 N239T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9450Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 P151A1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9501Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 P151H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Unaltered Function | 2 | submitted | EID9493Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 P190L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9504Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 P278A1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9509Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R174K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9503Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R174W1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Unaltered Function | 2 | submitted | EID9494Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R181P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9445Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R248L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9459Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R249G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9460Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R249S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9461Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R267Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9508Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R273C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9464Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R273H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9465Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R283P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9510Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R337C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9511Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 R337H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9512Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 S183L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9446Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 S241C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9439Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 T125R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9498Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 V173L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9442Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 V272L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Unaltered Function | 2 | submitted | EID9495Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |
| TP53 Y220C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9506Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements (REs) in… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC | civic |