Publication
PIK3CA mutations predict local recurrences in rectal cancer patients.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (10)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 10
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- cancerRectal Carcinomacivic_curation1.00
- geneBRAFcivic_curation1.00
- geneKRAScivic_curation1.00
- genePIK3CAcivic_curation1.00
- variantBRAF V600Ecivic_curation1.00
- variantKRAS Exon 2 Mutationcivic_curation1.00
- variantPIK3CA E545Kcivic_curation1.00
- variantPIK3CA Exon 10 Mutationcivic_curation1.00
- variantPIK3CA Exon 21 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19903786
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E1 | ||||||||
| (prognostic) | Malignant Colorectal NeoplasmCURATED_BROADER | Prognostic | C | Does Not Support Poor Outcome | 2 | accepted | EID2362This study examined outcomes of 240 rectum cancer patients treated with total mesorectal excision therapy. Tumor samples were obtained at the time of surgery and genotyped for BRAF exon 15 mutations. … (full text at CIViC) PMID 19903786 · He et al., 2009 · Open in CIViC | civic |
| PIK3CA H1047R1 | ||||||||
| Cetuximab | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | B | Supports Resistance | — | submitted | EID3731Rectal cancer patients with PIK3CA mutations showed a higher risk of local recurrence (HR:3.5; 95% CI:1.3-9.3, P=0.013, univariate analysis; HR:3.4, 95% CI:1.2-9.2, P=0.017, multivariate analysis) com… (full text at CIViC) PMID 19903786 · He et al., 2009 · Open in CIViC | civic |
| KRAS Exon 2 Mutation1 | ||||||||
| (prognostic) | Rectal CarcinomaALIAS | Prognostic | B | Does Not Support Poor Outcome | 2 | accepted | EID4052This study examined outcomes of 240 rectum cancer patients treated with total mesorectal excision therapy. Tumor samples were obtained at the time of surgery and genotyped for KRAS exon 2 mutations (l… (full text at CIViC) PMID 19903786 · He et al., 2009 · Open in CIViC | civic |
| PIK3CA E545K1 | ||||||||
| (prognostic) | Rectal CarcinomaALIAS | Prognostic | B | Supports Poor Outcome | 2 | accepted | EID2106This study examined outcomes of 240 rectum cancer patients treated with total mesorectal excision therapy. Tumor samples were obtained at the time of surgery and genotyped for PIK3CA exon 10 and 21 mu… (full text at CIViC) PMID 19903786 · He et al., 2009 · Open in CIViC | civic |
| PIK3CA Exon 10 Mutation + PIK3CA Exon 21 Mutation1 | ||||||||
| (prognostic) | Rectal CarcinomaALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID7220This study examined outcomes of 240 rectum cancer patients treated with total mesorectal excision therapy. Tumor samples were obtained at the time of surgery and genotyped for PIK3CA mutations in exon… (full text at CIViC) PMID 19903786 · He et al., 2009 · Open in CIViC | civic |