KIT T670I

CI-VAR-00004334Explore in graph →NP_000213.1:p.Thr670IleNM_000222.2:c.2009C>TClinVar 376058 CIViC 1267 rs121913516

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor5
KIT T670I	Imatinib	Predictive	C	Supports Resistance	3	accepted	EID2924 147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC	civic
KIT T670I	Imatinib	Predictive	D	Supports Resistance	5	accepted	EID7416 A preclinical study tested the effects of a tyrosine kinase inhibitor (TKI) on Ba/F3 cell lines with representative primary imatinib-sensitizing mutation del 557-558, which induced IL-3 independent gr… (full text at CIViC) PMID 25239608 · Garner et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376058	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Gastrointestinal stromal tumor; Hereditary cancer-predisposing syndrome	germline	2	Jan 28, 2025	clinvar

Solid Neoplasm1
KIT T670I	Dasatinib	Predictive	D	Supports Resistance	—	submitted	EID4509 In an in vitro study of gastrointestinal tumors, the HEK-293 cells expressing KIT V559D (a known sensitizing mutation to dasatinib) and T670I co-mutation was found to have reduced sensitivity to dasat… (full text at CIViC) PMID 16046538 · Carter et al., 2005 · Open in CIViC	civic