Publication
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMalignant Neoplasmcivic_curation1.00
- drugDasatinibcivic_curation1.00
- drugImatinibcivic_curation1.00
- drugPD-180970civic_curation1.00
- drugSunitinibcivic_curation1.00
- drugTandutinibcivic_curation1.00
- geneKITcivic_curation1.00
- variantKIT V559Dcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16046538
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT V559D2 | ||||||||
| Dasatinib + Imatinib + PD-180970 + Sunitinib + TandutinibSubstitutes | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID3029KIT(V559D) were expressed in HEK-293 cells (in vitro). Imatinib, BMS-354825 (dasatinib), PD-180970, MLN-518 (tandutinib), and SU-11248 bind variant V559D with high affinity (Kd =< 20 nM), and inhibit … (full text at CIViC) PMID 16046538 · Carter et al., 2005 · Open in CIViC | civic |
| Dasatinib | Solid NeoplasmCURATED_BROADER | Predictive | D | Supports Sensitivity Response | — | rejected | EID4114In an in vitro study of gastrointestinal tumors, HEK-293 cells expressing KIT V559D mutation were found to have sensitivity to dasatinib treatment. (IC50: 8nM). Sensitivity was determined by assessin… (full text at CIViC) PMID 16046538 · Carter et al., 2005 · Open in CIViC | civic |
| KIT T670I1 | ||||||||
| Dasatinib | Solid NeoplasmCURATED_BROADER | Predictive | D | Supports Resistance | — | submitted | EID4509In an in vitro study of gastrointestinal tumors, the HEK-293 cells expressing KIT V559D (a known sensitizing mutation to dasatinib) and T670I co-mutation was found to have reduced sensitivity to dasat… (full text at CIViC) PMID 16046538 · Carter et al., 2005 · Open in CIViC | civic |