Publication
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (57)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 57
- geneTP53civic_curation1.00
- variantTP53 A276Vcivic_curation1.00
- variantTP53 C242Ycivic_curation1.00
- variantTP53 D259Vcivic_curation1.00
- variantTP53 D281Ecivic_curation1.00
- variantTP53 D281Ncivic_curation1.00
- variantTP53 E224Kcivic_curation1.00
- variantTP53 E258Kcivic_curation1.00
- variantTP53 E286Kcivic_curation1.00
- variantTP53 G244Scivic_curation1.00
- variantTP53 G245Dcivic_curation1.00
- variantTP53 G245Scivic_curation1.00
- variantTP53 G262Dcivic_curation1.00
- variantTP53 G266Ecivic_curation1.00
- variantTP53 G266Rcivic_curation1.00
- variantTP53 G279Ecivic_curation1.00
- variantTP53 H168Ycivic_curation1.00
- variantTP53 H179Ycivic_curation1.00
- variantTP53 I162Fcivic_curation1.00
- variantTP53 K139Ecivic_curation1.00
- variantTP53 L252Fcivic_curation1.00
- variantTP53 L257Pcivic_curation1.00
- variantTP53 L308Mcivic_curation1.00
- variantTP53 L323Pcivic_curation1.00
- variantTP53 M246Lcivic_curation1.00
- variantTP53 N239Scivic_curation1.00
- variantTP53 P151Hcivic_curation1.00
- variantTP53 P151Scivic_curation1.00
- variantTP53 P152Lcivic_curation1.00
- variantTP53 P152Tcivic_curation1.00
- variantTP53 P177Fcivic_curation1.00
- variantTP53 P177Hcivic_curation1.00
- variantTP53 P177Scivic_curation1.00
- variantTP53 P219Hcivic_curation1.00
- variantTP53 P278Scivic_curation1.00
- variantTP53 P98Lcivic_curation1.00
- variantTP53 P98Scivic_curation1.00
- variantTP53 Q144Pcivic_curation1.00
- variantTP53 R156Pcivic_curation1.00
- variantTP53 R158Hcivic_curation1.00
- variantTP53 R181Ccivic_curation1.00
- variantTP53 R181Gcivic_curation1.00
- variantTP53 R181Hcivic_curation1.00
- variantTP53 R248Wcivic_curation1.00
- variantTP53 R273Ccivic_curation1.00
- variantTP53 R283Hcivic_curation1.00
- variantTP53 S241Fcivic_curation1.00
- variantTP53 S241Tcivic_curation1.00
- variantTP53 T230Scivic_curation1.00
- variantTP53 V274Fcivic_curation1.00
- variantTP53 Y126Dcivic_curation1.00
- variantTP53 Y126Scivic_curation1.00
- variantTP53 Y163Hcivic_curation1.00
- variantTP53 Y163Ncivic_curation1.00
- variantTP53 Y220Hcivic_curation1.00
- variantTP53 Y234Hcivic_curation1.00
- variantTP53 Y236Scivic_curation1.00
Curated evidence
Evidence citing this paper (57)
50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 11896595
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 Y126D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10217A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y126S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10218A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y163H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10225A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y163N1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10272A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y220H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10239A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y234H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10241A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Y236S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10226A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |