Publication
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (57)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 57
- geneTP53civic_curation1.00
- variantTP53 A276Vcivic_curation1.00
- variantTP53 C242Ycivic_curation1.00
- variantTP53 D259Vcivic_curation1.00
- variantTP53 D281Ecivic_curation1.00
- variantTP53 D281Ncivic_curation1.00
- variantTP53 E224Kcivic_curation1.00
- variantTP53 E258Kcivic_curation1.00
- variantTP53 E286Kcivic_curation1.00
- variantTP53 G244Scivic_curation1.00
- variantTP53 G245Dcivic_curation1.00
- variantTP53 G245Scivic_curation1.00
- variantTP53 G262Dcivic_curation1.00
- variantTP53 G266Ecivic_curation1.00
- variantTP53 G266Rcivic_curation1.00
- variantTP53 G279Ecivic_curation1.00
- variantTP53 H168Ycivic_curation1.00
- variantTP53 H179Ycivic_curation1.00
- variantTP53 I162Fcivic_curation1.00
- variantTP53 K139Ecivic_curation1.00
- variantTP53 L252Fcivic_curation1.00
- variantTP53 L257Pcivic_curation1.00
- variantTP53 L308Mcivic_curation1.00
- variantTP53 L323Pcivic_curation1.00
- variantTP53 M246Lcivic_curation1.00
- variantTP53 N239Scivic_curation1.00
- variantTP53 P151Hcivic_curation1.00
- variantTP53 P151Scivic_curation1.00
- variantTP53 P152Lcivic_curation1.00
- variantTP53 P152Tcivic_curation1.00
- variantTP53 P177Fcivic_curation1.00
- variantTP53 P177Hcivic_curation1.00
- variantTP53 P177Scivic_curation1.00
- variantTP53 P219Hcivic_curation1.00
- variantTP53 P278Scivic_curation1.00
- variantTP53 P98Lcivic_curation1.00
- variantTP53 P98Scivic_curation1.00
- variantTP53 Q144Pcivic_curation1.00
- variantTP53 R156Pcivic_curation1.00
- variantTP53 R158Hcivic_curation1.00
- variantTP53 R181Ccivic_curation1.00
- variantTP53 R181Gcivic_curation1.00
- variantTP53 R181Hcivic_curation1.00
- variantTP53 R248Wcivic_curation1.00
- variantTP53 R273Ccivic_curation1.00
- variantTP53 R283Hcivic_curation1.00
- variantTP53 S241Fcivic_curation1.00
- variantTP53 S241Tcivic_curation1.00
- variantTP53 T230Scivic_curation1.00
- variantTP53 V274Fcivic_curation1.00
- variantTP53 Y126Dcivic_curation1.00
- variantTP53 Y126Scivic_curation1.00
- variantTP53 Y163Hcivic_curation1.00
- variantTP53 Y163Ncivic_curation1.00
- variantTP53 Y220Hcivic_curation1.00
- variantTP53 Y234Hcivic_curation1.00
- variantTP53 Y236Scivic_curation1.00
Curated evidence
Evidence citing this paper (57)
50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 11896595
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 A276V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10232A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 C242Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10251A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 D259V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10269A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 D281E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10260A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 D281N1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10259A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 E224K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10240A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 E258K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10228A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 E286K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10270A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G177E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | submitted | EID10263A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G244S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10252A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G245D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10254A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G245S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10253A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G262D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10229A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G266E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10231A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G266R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10230A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 G279E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10258A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 H168Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10243A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 H179Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10247A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 I162F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10224A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 K139E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10219A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 L252F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10227A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 L257P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10273A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 L308M1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10234CAUTION: This Evidence Item has not been accepted as accurate or complete! A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (domi… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 L323P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10235A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 M246L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10255A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 N239S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10248A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P151H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10222A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P151S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10220A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P152L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10223A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P152T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10264A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P177F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10245A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P177H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10246A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P177S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10244A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P219H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10238A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P278S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10233A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P98L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10216A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 P98S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10215A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 Q144P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10236A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R156P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10265A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R158H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10237A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R181C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10266A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R181G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10267A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R181H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10268A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R248W1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10261A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R273C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10256A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 R283H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 2 | accepted | EID10271A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 S241F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10250A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 S241T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10249A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 T230S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10242A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |
| TP53 V274F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10257A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC | civic |