BRAF V600E

SNV

Identifier: CI-VAR-00004575
Entity page: /variant/braf-v600e ↗
Edges: 89

Neighbours: 24 cancers9 drugs
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BRAF V600E predicts response to …PREDICTS_RESPONSE_TO17 of 55show all (up to 200)
→ predicts response to	Dabrafenibsmall_molecule 3 source records aggregated	sensitivity	A	Low Grade Glioma,Lung Non-Small Cell Carcinoma,Solid Neoplasm	3	Curated	civic	graph →

BRAF V600E prognostic in …PROGNOSTIC_IN7 of 7
→ prognostic in	Thyroid Gland Papillary Carcinomasubtype 7 source records aggregated	supports	B	Thyroid Gland Papillary Carcinoma	7	Curated	civic	graph →
→ prognostic in	Malignant Colorectal Neoplasmsubtype 5 source records aggregated	supports	B	Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ prognostic in	Colorectal Adenocarcinomasubtype	supports	B	Colorectal Adenocarcinoma	1	Curated	civic	graph →
→ prognostic in	Colon Carcinomasubtype	supports	B	Colon Carcinoma	1	Curated	civic	graph →
→ prognostic in	Multiple Myelomahematologic_malignancy	supports	B	Multiple Myeloma	1	Curated	civic	graph →
→ prognostic in	Melanomacancer_family	supports	B	Melanoma	1	Curated	civic	graph →
→ prognostic in	Childhood Low Grade Gliomasubtype	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →

BRAF V600E prognostic in …PROGNOSTIC_IN7 of 7

→ prognostic in

Thyroid Gland Papillary Carcinomasubtype

7 source records aggregated

supports

Thyroid Gland Papillary Carcinoma

Curated

BRAF V600E diagnostic of …DIAGNOSTIC_OF3 of 3
→ diagnostic of	Malignant Thyroid Gland Neoplasmcancer	supports	B	Malignant Thyroid Gland Neoplasm	1	Curated	civic	graph →
→ diagnostic of	Hairy Cell Leukemiahematologic_malignancy	supports	B	Hairy Cell Leukemia	1	Curated	civic	graph →
→ diagnostic of	Thyroid Gland Papillary Carcinomasubtype	supports	B	Thyroid Gland Papillary Carcinoma	1	Curated	civic	graph →

BRAF V600E has curated evidence in …HAS_EVIDENCE_INderived24 of 24show fewer
→ has curated evidence in	Malignant Colorectal Neoplasmsubtype 37 accepted items · levels A, B, C, D, E · 20 sensitivity / 11 resistance · 32 supports / 5 does not support	mixed	A	Malignant Colorectal Neoplasm	37	Curated	civic	graph →
→ has curated evidence in	Childhood Low Grade Gliomasubtype 2 accepted items · levels A, B · 1 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Childhood Low Grade Glioma	2	Curated	civic	graph →
→ has curated evidence in	Cutaneous Melanoma 2 accepted items · levels A, B · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Cutaneous Melanoma	2	Curated	civic	graph →
→ has curated evidence in	Low Grade Glioma 2 accepted items · levels A, B · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Low Grade Glioma	2	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinoma 2 accepted items · levels A, B · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has curated evidence in	Solid Neoplasm 1 accepted items · levels A · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	A	Solid Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Melanomacancer_family 31 accepted items · levels B, C, D · 20 sensitivity / 9 resistance · 28 supports / 3 does not support	mixed	B	Melanoma	31	Curated	civic	graph →
→ has curated evidence in	Thyroid Gland Papillary Carcinomasubtype 12 accepted items · levels B, C · 3 sensitivity / 0 resistance · 11 supports / 1 does not support	sensitivity	B	Thyroid Gland Papillary Carcinoma	12	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 4 accepted items · levels B, D · 4 sensitivity / 0 resistance · 2 supports / 2 does not support	sensitivity	B	Malignant Neoplasm	4	Curated	civic	graph →
→ has curated evidence in	Multiple Myelomahematologic_malignancy 3 accepted items · levels B, C · 2 sensitivity / 0 resistance · 3 supports / 0 does not support	sensitivity	B	Multiple Myeloma	3	Curated	civic	graph →
→ has curated evidence in	Thyroid Gland Anaplastic Carcinoma 3 accepted items · levels B, C · 3 sensitivity / 0 resistance · 3 supports / 0 does not support	sensitivity	B	Thyroid Gland Anaplastic Carcinoma	3	Curated	civic	graph →
→ has curated evidence in	Hairy Cell Leukemiahematologic_malignancy 2 accepted items · levels B · 1 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	B	Hairy Cell Leukemia	2	Curated	civic	graph →
→ has curated evidence in	Colon Carcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Colon Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Colorectal Adenocarcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Colorectal Adenocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Langerhans Cell Sarcoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Langerhans Cell Sarcoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Biliary Tract Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Thyroid Gland Neoplasmcancer 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Malignant Thyroid Gland Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Cholangiocarcinoma 2 accepted items · levels C · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	C	Cholangiocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Intrahepatic Cholangiocarcinoma 2 accepted items · levels C · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	C	Intrahepatic Cholangiocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Childhood Pilocytic Astrocytoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Childhood Pilocytic Astrocytoma	1	Curated	civic	graph →
→ has curated evidence in	Digestive System Neuroendocrine Tumor 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →
→ has curated evidence in	Laryngeal Squamous Cell Carcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Laryngeal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Ovarian Serous Adenocarcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Ovarian Serous Adenocarcinoma	1	Curated	civic	graph →

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