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Knowledge graph · Gene

U2AF1

U2 small nuclear RNA auxiliary factor 1

Identifier: CI-GENE-00037672
Entity page: /gene/U2AF1 ↗
Edges: 9

Neighbours: 2 cancers6 variants
Drawn: 8 of 8 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
U2AF1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Myelodysplastic Syndromehematologic_malignancy 2 source records aggregated	supports	B	Myelodysplastic Syndrome	2	Curated	civic	graph →
→ associated with	Primary Myelofibrosishematologic_malignancy	supports

U2AF1 has variant …HAS_VARIANTderived6 of 6
→ has variant	Q157P/RSNV 3 accepted CIViC evidence items	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia	3	Curated	civic	graph →
→ has variant	S34Y/FSNV 2 accepted CIViC evidence items	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia	2	Curated	civic	graph →
→ has variant	MUTATIONother 1 accepted CIViC evidence items	—	—	Primary Myelofibrosis	1	Curated	civic	graph →
→ has variant	I24TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006758.3(U2AF1):c.101C>T (p.Ser34Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006758.3(U2AF1):c.467G>A (p.Arg156His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

U2AF1 has variant …HAS_VARIANTderived6 of 6

→ has variant

Q157P/RSNV

3 accepted CIViC evidence items

—

Myelodysplastic Syndrome,Acute Myeloid Leukemia

Curated

civic

graph →

→ has variant

S34Y/FSNV

2 accepted CIViC evidence items

—

Myelodysplastic Syndrome,Acute Myeloid Leukemia

Curated

civic

graph →

→ has variant

MUTATIONother

1 accepted CIViC evidence items

—

Primary Myelofibrosis

Curated

civic

graph →

→ has variant

I24TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_006758.3(U2AF1):c.101C>T (p.Ser34Phe)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_006758.3(U2AF1):c.467G>A (p.Arg156His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

U2AF1 altered in cohorts of …ALTERED_INderived1 of 1
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 289 / 3,323 cases (8.7 %) · ssm · mds_iwg_2022	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →

U2AF1 altered in cohorts of …ALTERED_INderived1 of 1

→ altered in cohorts of

Myelodysplastic Syndromehematologic_malignancy

289 / 3,323 cases (8.7 %) · ssm · mds_iwg_2022

—

Myelodysplastic Syndrome

Observed

cbioportal

graph →

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