U2AF1 I24T

CI-VAR-00001990Explore in graph →CIViC 3758

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
U2AF1 I24T	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID10212 Analysis of the U2AF small subunit (U2AF23) in fission yeast, U2AF35 in humans, found that mutation I24T is at the interface between the zinc finger motifs and results in a threefold RNA-binding activ… (full text at CIViC) PMID 26215567 · Yoshida et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.