U2AF1 Q157P/R

CI-VAR-00003497Explore in graph →CIViC 127

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia2
U2AF1 Q157P/R	(diagnostic)	Diagnostic	B	Does Not Support Positive	3	submitted	EID217 Age, sex, FAB subtype and karyotypes were not statistically significant between AML patients with U2AF Q157P/R mutations and those who harbor wild type U2AF. PMID 23029227 · Qian et al., 2012 · Open in CIViC	civic
U2AF1 Q157P/R	(prognostic)	Prognostic	B	Does Not Support N/A	2	accepted	EID338 In patients with AML, those who harbor Q157P/R mutation of U2AF1 do not show a statistically significant difference in complete remission rate compared to those who harbor wild type U2AF1. PMID 23029227 · Qian et al., 2012 · Open in CIViC	civic
Myelodysplastic Syndrome

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.