RB1

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RB1 associated with …ASSOCIATED_WITH6 of 6
→ associated with	Lung Non-Small Cell Carcinomasubtype 2 source records aggregated	supports	B	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ associated with	Malignant Breast Neoplasmcancer_family 2 source records aggregated

RB1 has variant …HAS_VARIANTderived200 of 4,479show all (up to 200)
→ has variant	Loss-of-function 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Glioblastoma	2	Curated	civic	graph →
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Lung Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	M695FS*26indel 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Pancreatic Adenocarcinoma	1	Curated	civic	graph →
→ has variant	PHOSPHORYLATION 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	Wildtypeother 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	IVS20, A-G, -2 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Lossdeletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.10:g.(?_48916729)_(48942746_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.10:g.(?_49027119)_(49030495_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303678_48303679delinsTTindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303678G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303679C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303679C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303680G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303680G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303681G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303681G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303682G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303683_48303684delinsAAindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303683C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303684C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303685C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303685deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303686G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303686G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303688G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303690G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303690G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303691C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303692_48303714deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303692C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303694C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303694C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303695G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303700C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303700C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303700C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303701G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303702T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303702T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303703G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303704A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303707C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303707C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303709G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303710C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303711G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303711G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303712G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303712G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303713G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303713G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303714_48303721deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303714C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303714C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303717A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303721G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303722A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303724G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303724G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303728T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303729C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303730C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303732G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303733C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303734G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303734G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303737T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303738G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303739G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303740A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303741C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303742G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303744G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303745deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303745G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303746C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303747G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303748C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303749T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303750C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48303903)_(48307416_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48303903)_(48480081_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48303907)_(48480077_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48303931_48303933delinsGGindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48307270)_(48349033_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48307274)_(48349029_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48342599)_(48345199_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48345070)_(48345209_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48345074)_(48345205_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48360007)_(48368614_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48376908)_(48380094_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48379594)_(48381443_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48464992)_(48465374_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48464999_48465023deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.48465329_48465332delinsTTTindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000013.11:g.(?_48476691)_(48477414_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.2(RB1):c.382_383dupGTother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1001G>A (p.Arg334Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1002del (p.Arg334fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1005A>G (p.Leu335=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1005del (p.Leu335fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1006T>C (p.Phe336Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1007T>G (p.Phe336Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.-100A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.100G>C (p.Glu34Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.100G>T (p.Glu34Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1010del (p.Leu337fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1010T>C (p.Leu337Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1010T>G (p.Leu337Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1011G>A (p.Leu337=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1012G>A (p.Asp338Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1013A>T (p.Asp338Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1014T>A (p.Asp338Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1015C>T (p.His339Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1016A>G (p.His339Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1016A>T (p.His339Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1017T>A (p.His339Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1017T>C (p.His339=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.-101A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1020T>A (p.Asp340Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1020T>G (p.Asp340Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1021A>T (p.Lys341Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1022A>G (p.Lys341Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.*1022C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1023A>T (p.Lys341Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1024A>T (p.Thr342Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1024del (p.Thr342fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1025C>T (p.Thr342Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1027_1028del (p.Leu343fs)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1027del (p.Leu343fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1029del (p.Gln344fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.102G>C (p.Glu34Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1030C>A (p.Gln344Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1030C>T (p.Gln344Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1031_1034del (p.Gln344fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1031A>G (p.Gln344Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1032G>A (p.Gln344=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1033A>T (p.Thr345Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1034C>G (p.Thr345Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1035T>G (p.Thr345=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1036G>C (p.Asp346His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1037A>C (p.Asp346Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1037A>G (p.Asp346Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1039dup (p.Ser347fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1039T>C (p.Ser347Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.103C>G (p.Gln35Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.103C>T (p.Gln35Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1040C>A (p.Ser347Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.-104_-103insTTTTTTTTTTTTTTTTTTTTNNNNNNNNNNGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGTGAAATTATTTTTinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1041T>A (p.Ser347=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1041T>G (p.Ser347=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1042A>G (p.Ile348Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1043T>C (p.Ile348Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.*1044T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1047_1049+168delinsATCAATAAindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1047C>G (p.Asp349Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1047C>T (p.Asp349=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1048A>T (p.Ser350Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+10A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+11T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+11T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+15A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+18T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+20T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+2T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+2T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+3A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+4T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+5T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+5T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+7C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+7C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+8A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049+8A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1049G>A (p.Ser350Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.104A>T (p.Gln35Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-11T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-11T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-12A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-15C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-17C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-1G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-20C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-2_1052deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-3T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-5T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-6A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-6A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-8_1050-2deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-9_1050-7deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-9G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000321.3(RB1):c.1050-9G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

RB1 has variant …HAS_VARIANTderived200 of 4,479show all (up to 200)

→ has variant

Loss-of-function

2 accepted CIViC evidence items

—

Malignant Breast Neoplasm,Glioblastoma

Curated

civic

graph →

→ has variant

Mutationother

2 accepted CIViC evidence items

—

Malignant Breast Neoplasm,Lung Small Cell Carcinoma

Curated

civic

graph →

→ has variant

EXPRESSIONexpression

1 accepted CIViC evidence items

—

Lung Non-Small Cell Carcinoma

Curated

civic

graph →

→ has variant

M695FS*26indel

1 accepted CIViC evidence items

—

not mapped

Curated

civic

graph →

→ has variant

Overexpressionexpression

1 accepted CIViC evidence items

—

Pancreatic Adenocarcinoma

Curated

civic

graph →

→ has variant

PHOSPHORYLATION

1 accepted CIViC evidence items

—

Malignant Breast Neoplasm

Curated

civic

graph →

→ has variant

Wildtypeother

1 accepted CIViC evidence items

—

Lung Non-Small Cell Carcinoma

Curated

civic

graph →

→ has variant

IVS20, A-G, -2

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

Lossdeletion_cna

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.10:g.(?_48916729)_(48942746_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.10:g.(?_49027119)_(49030495_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303678_48303679delinsTTindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303678G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303679C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303679C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303680G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303680G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303681G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303681G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303682G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303683_48303684delinsAAindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303683C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303684C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303685C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303685deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303686G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303686G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303688G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303690G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303690G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303691C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303692_48303714deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303692C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303694C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303694C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303695G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303700C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303700C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303700C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303701G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303702T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303702T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303703G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303704A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303707C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303707C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303709G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303710C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303711G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303711G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303712G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303712G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303713G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303713G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303714_48303721deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303714C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303714C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303717A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303721G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303722A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303724G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303724G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303728T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303729C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303730C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303732G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303733C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303734G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303734G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303737T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303738G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303739G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303740A>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303741C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303742G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303744G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303745deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303745G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303746C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303747G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303748C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303749T>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303750C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48303903)_(48307416_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48303903)_(48480081_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48303907)_(48480077_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48303931_48303933delinsGGindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48307270)_(48349033_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48307274)_(48349029_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48342599)_(48345199_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48345070)_(48345209_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48345074)_(48345205_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48360007)_(48368614_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48376908)_(48380094_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48379594)_(48381443_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48464992)_(48465374_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48464999_48465023deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.48465329_48465332delinsTTTindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000013.11:g.(?_48476691)_(48477414_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.2(RB1):c.382_383dupGTother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1001G>A (p.Arg334Lys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1002del (p.Arg334fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1005A>G (p.Leu335=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1005del (p.Leu335fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1006T>C (p.Phe336Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1007T>G (p.Phe336Cys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.-100A>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.100G>C (p.Glu34Gln)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.100G>T (p.Glu34Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1010del (p.Leu337fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1010T>C (p.Leu337Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1010T>G (p.Leu337Trp)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1011G>A (p.Leu337=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1012G>A (p.Asp338Asn)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1013A>T (p.Asp338Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1014T>A (p.Asp338Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1015C>T (p.His339Tyr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1016A>G (p.His339Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1016A>T (p.His339Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1017T>A (p.His339Gln)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1017T>C (p.His339=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.-101A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1020T>A (p.Asp340Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1020T>G (p.Asp340Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1021A>T (p.Lys341Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1022A>G (p.Lys341Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.*1022C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1023A>T (p.Lys341Asn)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1024A>T (p.Thr342Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1024del (p.Thr342fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1025C>T (p.Thr342Ile)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1027_1028del (p.Leu343fs)other

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1027del (p.Leu343fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1029del (p.Gln344fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.102G>C (p.Glu34Asp)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1030C>A (p.Gln344Lys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1030C>T (p.Gln344Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1031_1034del (p.Gln344fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1031A>G (p.Gln344Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1032G>A (p.Gln344=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1033A>T (p.Thr345Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1034C>G (p.Thr345Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1035T>G (p.Thr345=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1036G>C (p.Asp346His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1037A>C (p.Asp346Ala)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1037A>G (p.Asp346Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1039dup (p.Ser347fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1039T>C (p.Ser347Pro)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.103C>G (p.Gln35Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.103C>T (p.Gln35Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1040C>A (p.Ser347Tyr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.-104_-103insTTTTTTTTTTTTTTTTTTTTNNNNNNNNNNGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGTGAAATTATTTTTinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1041T>A (p.Ser347=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1041T>G (p.Ser347=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1042A>G (p.Ile348Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1043T>C (p.Ile348Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.*1044T>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1047_1049+168delinsATCAATAAindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1047C>G (p.Asp349Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1047C>T (p.Asp349=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1048A>T (p.Ser350Cys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+10A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+11T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+11T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+15A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+18T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+1G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+1G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+20T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+2T>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+2T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+3A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+4T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+5T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+5T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+7C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+7C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+8A>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049+8A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1049G>A (p.Ser350Asn)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.104A>T (p.Gln35Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-11T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-11T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-12A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-15C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-17C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-1G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-1G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-1G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-20C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-2_1052deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-2A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-3T>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-5T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-6A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-6A>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-8_1050-2deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-9_1050-7deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-9G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000321.3(RB1):c.1050-9G>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

RB1 altered in cohorts of …ALTERED_INderived10 of 10
→ altered in cohorts of	Lung Small Cell Carcinomasubtype 87 / 120 cases (73 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Sarcoma 165 / 261 cases (63 %) · ssm · TCGA-SARC	—	—	Sarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Retinoblastoma 52 / 83 cases (63 %) · ssm · rbl_mskcc_2020	—	—	Retinoblastoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 100 / 474 cases (21 %) · ssm · blca_msk_tcga_2020 · largest of 9 cohorts	—	—	Bladder Urothelial Carcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 54 / 527 cases (10 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 29 / 322 cases (9.0 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 86 / 1,004 cases (8.6 %) · ssm · glioma_mskcc_2019 · largest of 7 cohorts	—	—	Diffuse Glioma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 36 / 494 cases (7.3 %) · ssm · hcc_clca_2024 · largest of 2 cohorts	—	—	Hepatocellular Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 44 / 696 cases (6.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 142 / 2,653 cases (5.4 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 2 cohorts	—	—	Lung Adenocarcinoma	2	Observed	cbioportal	graph →

RB1 altered in cohorts of …ALTERED_INderived10 of 10

→ altered in cohorts of

Lung Small Cell Carcinomasubtype

87 / 120 cases (73 %) · ssm · sclc_ucologne_2015

—

Lung Small Cell Carcinoma

Observed

cbioportal

graph →

→ altered in cohorts of

Sarcoma

165 / 261 cases (63 %) · ssm · TCGA-SARC