PTGS2

prostaglandin-endoperoxide synthase 2

Identifier: CI-GENE-00022450
Entity page: /gene/PTGS2 ↗
Edges: 8

Neighbours: 3 variants5 drugs
Drawn: 8 of 8 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PTGS2 targets …TARGETS5 of 5
← targets	Sulindacsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Meloxicamsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

PTGS2 has variant …HAS_VARIANTderived3 of 3
→ has variant	NC_000001.11:g.186681189C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000963.4(PTGS2):c.*427T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	Overexpressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

PTGS2 has variant …HAS_VARIANTderived3 of 3

→ has variant

NC_000001.11:g.186681189C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000963.4(PTGS2):c.*427T>CSNV

no accepted CIViC evidence item (variant record only)