PRKDC

protein kinase, DNA-activated, catalytic subunit

Identifier: CI-GENE-00021016
Entity page: /gene/PRKDC ↗
Edges: 32

Neighbours: 13 cancers19 variants
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PRKDC associated with …ASSOCIATED_WITH2 of 2
→ associated with	Melanomacancer_family	supports	B	Melanoma	1	Curated	civic	graph →
→ associated with	Lung Non-Small Cell Carcinomasubtype	supports	B

PRKDC has variant …HAS_VARIANTderived19 of 19show fewer
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Melanoma,Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.1289dup (p.Tyr431fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.1455G>A (p.Gln485=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.1704T>G (p.Phe568Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.2782-5T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.2861G>T (p.Gly954Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.2918C>T (p.Ala973Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.291C>T (p.Gly97=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.2934+5G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.3212A>G (p.Asn1071Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.3347C>T (p.Ala1116Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.3463C>T (p.Arg1155Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.5364G>A (p.Arg1788=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.8157G>A (p.Ala2719=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.8274G>A (p.Lys2758=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.8784-8T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.9337-5_9337-4deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.9446G>A (p.Gly3149Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006904.7(PRKDC):c.9462A>G (p.Gln3154=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PRKDC has variant …HAS_VARIANTderived19 of 19show fewer

→ has variant

Mutationother

2 accepted CIViC evidence items

—

Melanoma,Lung Non-Small Cell Carcinoma

Curated

PRKDC altered in cohorts of …ALTERED_INderived11 of 11
→ altered in cohorts of	Endometrial Carcinoma 88 / 517 cases (17 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 38 / 247 cases (15 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 20 / 134 cases (15 %) · ssm · brca_aurora_2023	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 44 / 429 cases (10 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 52 / 534 cases (9.7 %) · ssm · coadread_tcga_pan_can_atlas_2018	—	—	Colorectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 49 / 518 cases (9.5 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 43 / 478 cases (9.0 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 21 / 291 cases (7.2 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 21 / 370 cases (5.7 %) · ssm · hcc_tcga_gdc · largest of 2 cohorts	—	—	Hepatocellular Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 29 / 515 cases (5.6 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 24 / 474 cases (5.1 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →

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