PIM1

Pim-1 proto-oncogene, serine/threonine kinase

Identifier: CI-GENE-00019767
Entity page: /gene/PIM1 ↗
Edges: 27

Neighbours: 5 cancers22 variants
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PIM1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ associated with	Diffuse Large B-Cell Lymphoma Activated B-Cell Typehematologic_malignancy 3 source records aggregated

PIM1 has variant …HAS_VARIANTderived22 of 22show fewer
→ has variant	L2VSNV 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	1	Curated	civic	graph →
→ has variant	NUCLEAR EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P81SSNV 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	1	Curated	civic	graph →
→ has variant	S97NSNV 1 accepted CIViC evidence items	—	—	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	1	Curated	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.115C>T (p.Gln39Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.128T>A (p.Leu43Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.176C>G (p.Ser59Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.208G>T (p.Glu70Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.233_240+7deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.237G>C (p.Glu79Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.290G>A (p.Ser97Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.291C>G (p.Ser97Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.293C>T (p.Ser98Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.3G>A (p.Met1Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.403G>A (p.Glu135Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.409G>T (p.Gly137Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.529C>T (p.Leu177Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.543G>C (p.Glu181Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.550C>T (p.Leu184Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.88G>A (p.Glu30Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002648.4(PIM1):c.97C>T (p.Pro33Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PIM1 has variant …HAS_VARIANTderived22 of 22show fewer

→ has variant

L2VSNV

1 accepted CIViC evidence items

—

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Curated

PIM1 altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	Primary Central Nervous System Lymphoma 33 / 86 cases (38 %) · ssm · pcnsl_msk_2024	—	—	Primary Central Nervous System Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 147 / 1,001 cases (15 %) · ssm · dlbcl_duke_2017 · largest of 2 cohorts	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	2	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 66 / 755 cases (8.7 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →

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