MUC4

mucin 4, cell surface associated

Identifier: CI-GENE-00015897
Entity page: /gene/MUC4 ↗
Edges: 38

Neighbours: 28 cancers10 variants
Drawn: 38 of 38 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MUC4 has variant …HAS_VARIANTderived10 of 10
→ has variant	NM_018406.7(MUC4):c.11989C>G (p.His3997Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018406.7(MUC4):c.12446T>G (p.Ile4149Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

MUC4 altered in cohorts of …ALTERED_INderived28 of 28show fewer
→ altered in cohorts of	Uterine Carcinosarcoma 45 / 57 cases (79 %) · ssm · TCGA-UCS	—	—	Uterine Carcinosarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Cervical Carcinoma 224 / 306 cases (73 %) · ssm · TCGA-CESC · largest of 2 cohorts	—	—	Cervical Carcinoma	2	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 372 / 528 cases (70 %) · ssm · TCGA-HNSC · largest of 2 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	2	Observed	gdc	graph →
→ altered in cohorts of	Chromophobe Renal Cell Carcinoma 46 / 66 cases (70 %) · ssm · kich_tcga	—	—	Chromophobe Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 27 / 39 cases (69 %) · ssm · cscc_hgsc_bcm_2014	—	—	Skin Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Carcinoma 128 / 185 cases (69 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Melanoma 37 / 144 cases (26 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Adrenal Cortical Carcinoma 21 / 90 cases (23 %) · ssm · acc_tcga	—	—	Adrenal Cortical Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 20 / 106 cases (19 %) · ssm · coad_cptac_2019	—	—	Colon Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 90 / 517 cases (17 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Endometrial Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 50 / 291 cases (17 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Clear Cell Renal Cell Carcinoma 77 / 451 cases (17 %) · ssm · kirc_tcga · largest of 2 cohorts	—	—	Clear Cell Renal Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 29 / 185 cases (16 %) · ssm · esca_tcga	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Non-Seminomatous Germ Cell Tumor 24 / 155 cases (15 %) · ssm · tgct_tcga	—	—	Non-Seminomatous Germ Cell Tumor	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 55 / 368 cases (15 %) · ssm · skcm_tcga · largest of 3 cohorts	—	—	Cutaneous Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 32 / 247 cases (13 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 67 / 518 cases (13 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 21 / 178 cases (12 %) · ssm · lusc_tcga_pub	—	—	Lung Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 46 / 478 cases (9.6 %) · ssm · stad_tcga	—	—	Gastric Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 26 / 297 cases (8.8 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 23 / 302 cases (7.6 %) · ssm · luad_oncosg_2020	—	—	Lung Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 69 / 1,026 cases (6.7 %) · ssm · mds_mskcc_2020	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 25 / 373 cases (6.7 %) · ssm · lihc_tcga	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 26 / 444 cases (5.9 %) · ssm · prad_su2c_2019 · largest of 2 cohorts	—	—	Prostate Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 59 / 1,015 cases (5.8 %) · ssm · crc_sysucc_2022 · largest of 2 cohorts	—	—	Colorectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 25 / 444 cases (5.6 %) · ssm · difg_glass_2019 · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 53 / 982 cases (5.4 %) · ssm · brca_tcga · largest of 2 cohorts	—	—	Invasive Breast Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 24 / 474 cases (5.1 %) · ssm · blca_msk_tcga_2020	—	—	Bladder Urothelial Carcinoma	1	Observed	cbioportal	graph →

MUC4 altered in cohorts of …ALTERED_INderived28 of 28show fewer

→ altered in cohorts of

Uterine Carcinosarcoma

45 / 57 cases (79 %) · ssm · TCGA-UCS

—

Uterine Carcinosarcoma

Observed

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