MTOR

mechanistic target of rapamycin kinase

Identifier: CI-GENE-00015849
Entity page: /gene/MTOR ↗
Edges: 70

Neighbours: 18 cancers15 variants8 drugs
Drawn: 41 of 41 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MTOR associated with …ASSOCIATED_WITH8 of 8
→ associated with	Solid Neoplasmcancer_family	supports	B	Solid Neoplasm	1	Curated	civic	graph →
→ associated with	Melanomacancer_family	supports	B

MTOR targets …TARGETS8 of 8
← targets	Vistusertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sapanisertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Samotolisibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ridaforolimussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Onatasertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Omipalisibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dactolisibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Apitolisibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

MTOR targets …TARGETS8 of 8

← targets

Vistusertibsmall_molecule

—

INHIBITOR

—

Curated

MTOR has variant …HAS_VARIANTderived15 of 43show all (up to 200)
→ has variant	Mutationother 3 accepted CIViC evidence items	—	—	Solid Neoplasm,Melanoma,Bladder Carcinoma	3	Curated	civic	graph →
→ has variant	A2034VSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	F2108LSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Thyroid Gland Anaplastic Carcinoma	2	Curated	civic	graph →
→ has variant	M2327ISNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	C1483YSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	E1799KSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	E2014KSNV 1 accepted CIViC evidence items	—	—	Transitional Cell Carcinoma	1	Curated	civic	graph →
→ has variant	E2419KSNV 1 accepted CIViC evidence items	—	—	Transitional Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H1968YSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	P2213SSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	R2152CSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	S2215YSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	T1977KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Alterationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C1483FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MTOR altered in cohorts of …ALTERED_INderived11 of 11
→ altered in cohorts of	Chromophobe Renal Cell Carcinoma 58 / 86 cases (67 %) · ssm · TCGA-KICH	—	—	Chromophobe Renal Cell Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 31 / 247 cases (13 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 26 / 248 cases (10 %) · ssm · ucec_tcga · largest of 3 cohorts	—	—	Endometrial Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 51 / 527 cases (9.7 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 64 / 696 cases (9.2 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 39 / 429 cases (9.1 %) · ssm · coad_tcga_gdc	—	—	Colon Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 50 / 619 cases (8.1 %) · ssm · coadread_dfci_2016	—	—	Colorectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Clear Cell Renal Cell Carcinoma 32 / 451 cases (7.1 %) · ssm · kirc_tcga · largest of 4 cohorts	—	—	Clear Cell Renal Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 23 / 352 cases (6.5 %) · ssm · rcc_cptac_gdc · largest of 2 cohorts	—	—	Renal Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 64 / 1,001 cases (6.4 %) · ssm · dlbcl_duke_2017	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 394 / 7,237 cases (5.4 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →

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