MLH1

mutL homolog 1

Identifier: CI-GENE-00014659
Entity page: /gene/MLH1 ↗
Edges: 6,076

Neighbours: 5 cancers15 variants
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MLH1 associated with …ASSOCIATED_WITH5 of 5
→ associated with	Gastric Carcinomasubtype 2 source records aggregated	supports	B	Gastric Carcinoma	2	Curated	civic	graph →
→ associated with	Malignant Neoplasmcancer_family	supports	B

MLH1 has variant …HAS_VARIANTderived15 of 6,071show all (up to 200)
→ has variant	*757LSNV 1 accepted CIViC evidence items	—	—	Villous Adenoma	1	Curated	civic	graph →
→ has variant	A424TSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	A681VSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	c.790+1G>Asplice 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	D667FSindel 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	E13fsindel 1 accepted CIViC evidence items	—	—	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has variant	EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Gastric Carcinoma	1	Curated	civic	graph →
→ has variant	G606FS*2indel 1 accepted CIViC evidence items	—	—	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has variant	G65DSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	G67RSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	I68SSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	K618DELdeletion 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Lossdeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	M1LSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	M490TSNV 1 accepted CIViC evidence items	—	—	Malignant Endometrial Neoplasm	1	Curated	civic	graph →

MLH1 has variant …HAS_VARIANTderived15 of 6,071show all (up to 200)

→ has variant

*757LSNV

1 accepted CIViC evidence items

—

Villous Adenoma

Curated

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