JAK1

Janus kinase 1

Identifier: CI-GENE-00006501
Entity page: /gene/JAK1 ↗
Edges: 37

Neighbours: 7 cancers15 variants3 drugs
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
JAK1 associated with …ASSOCIATED_WITH4 of 4
→ associated with	Sarcomacancer_family	supports	C	Sarcoma	1	Curated	civic	graph →
→ associated with	Cutaneous Melanomacancer	supports	C

JAK1 targets …TARGETS3 of 3
← targets	Tofacitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ruxolitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Momelotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

JAK1 has variant …HAS_VARIANTderived15 of 26show all (up to 200)
→ has variant	OVEREXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Sarcoma,Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	Q503*SNV 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	S703ISNV 1 accepted CIViC evidence items	—	—	Hepatocellular Carcinoma	1	Curated	civic	graph →
→ has variant	A1086SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E483DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	N451SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1335-7C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1374C>T (p.Ser458=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.152G>T (p.Gly51Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1648+5G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1954T>A (p.Tyr652Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1965C>T (p.Gly655=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.1972G>T (p.Val658Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002227.4(JAK1):c.2049C>T (p.Ser683=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

JAK1 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 43 / 247 cases (17 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 52 / 527 cases (9.9 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 171 / 1,882 cases (9.1 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinomasubtype 28 / 494 cases (5.7 %) · ssm · hcc_clca_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →

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