IKZF1

IKAROS family zinc finger 1

Identifier: CI-GENE-00005994
Entity page: /gene/IKZF1 ↗
Edges: 35

Neighbours: 4 cancers30 variants
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
IKZF1 associated with …ASSOCIATED_WITH3 of 3
→ associated with	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy 2 source records aggregated	supports	A	B Lymphoblastic Leukemia/Lymphoma	2	Curated	civic	graph →
→ associated with	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy

IKZF1 has variant …HAS_VARIANTderived30 of 30show fewer
→ has variant	Deletiondeletion_cna 10 accepted CIViC evidence items	—	—	Acute Lymphoblastic Leukemia,B Lymphoblastic Leukemia/Lymphoma	10	Curated	civic	graph →
→ has variant	Loss-of-function 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	D186fs (c.556del)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	IKZF1 deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1034G>A (p.Ser345Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1047G>C (p.Gln349His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1178G>C (p.Ser393Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1193C>T (p.Thr398Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1405G>C (p.Val469Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1474T>G (p.Cys492Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1531C>T (p.Arg511Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.1535G>T (p.Gly512Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.161-8254G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.161-8275C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.161-8401C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.161-8414T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.*2279T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.247C>T (p.Arg83Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.26T>C (p.Met9Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.271A>T (p.Lys91Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.331C>T (p.Arg111Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.336_337insGA (p.Pro113fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.398T>C (p.Met133Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.436_438delinsGGGCTCCCTAA (p.Gln146fs)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.450C>A (p.Cys150Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.475A>T (p.Asn159Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.530T>C (p.Leu177Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.590-63A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.851-1312A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006060.6(IKZF1):c.983G>T (p.Arg328Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

IKZF1 has variant …HAS_VARIANTderived30 of 30show fewer

→ has variant

Deletiondeletion_cna

10 accepted CIViC evidence items

—

Acute Lymphoblastic Leukemia,B Lymphoblastic Leukemia/Lymphoma

Curated

IKZF1 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Skin Basal Cell Carcinoma 46 / 293 cases (16 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 94 / 696 cases (14 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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