GNAS

GNAS complex locus

Identifier: CI-GENE-00003199
Entity page: /gene/GNAS ↗
Edges: 40

Neighbours: 18 cancers15 variants
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
GNAS associated with …ASSOCIATED_WITH13 of 13
→ associated with	Pseudomyxoma Peritoneisubtype 2 source records aggregated	supports	B	Pseudomyxoma Peritonei	2	Curated	civic	graph →
→ associated with	Lung Non-Small Cell Carcinomasubtype	supports

GNAS has variant …HAS_VARIANTderived15 of 21show all (up to 200)
→ has variant	c.393T>CSNV 9 accepted CIViC evidence items	—	—	Melanoma,Breast Carcinoma,Malignant Esophageal Neoplasm+2	9	Curated	civic	graph →
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Malignant Appendix Neoplasm,Pseudomyxoma Peritonei	2	Curated	civic	graph →
→ has variant	R201SNV 1 accepted CIViC evidence items	—	—	Pseudomyxoma Peritonei	1	Curated	civic	graph →
→ has variant	R201CSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R201HSNV 1 accepted CIViC evidence items	—	—	Thyroid Gland Follicular Carcinoma	1	Curated	civic	graph →
→ has variant	NM_000516.7(GNAS):c.180_185del (p.Met60_Arg61del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.213-1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.219C>T (p.Gly73=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.258-138A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.305C>T (p.Ala102Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.312+5G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.432+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.531-13_531-10delother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.53C>T (p.Ala18Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000516.7(GNAS):c.586-42G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

GNAS has variant …HAS_VARIANTderived15 of 21show all (up to 200)

→ has variant

c.393T>CSNV

9 accepted CIViC evidence items

—

Melanoma,Breast Carcinoma,Malignant Esophageal Neoplasm+2

Curated

GNAS altered in cohorts of …ALTERED_INderived6 of 6
→ altered in cohorts of	Rectal Adenocarcinoma 150 / 171 cases (88 %) · ssm · TCGA-READ	—	—	Rectal Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Colon Adenocarcinoma 332 / 461 cases (72 %) · ssm · TCGA-COAD	—	—	Colon Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 281 / 443 cases (63 %) · ssm · TCGA-STAD	—	—	Gastric Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Appendix Adenocarcinoma 91 / 273 cases (33 %) · ssm · appendiceal_msk_2022	—	—	Appendix Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 45 / 293 cases (15 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 21 / 417 cases (5.0 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →

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