GNAS R201H

CI-VAR-00003755Explore in graph →CIViC 1319

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Appendix Neoplasm1
GNAS R201H	Trametinib	Predictive	C	Supports Sensitivity Response	2	submitted	EID8676 Case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation and had clinical benefit for 4 mo… (full text at CIViC) PMID 28868010 · Ang et al., 2017 · Open in CIViC	civic
Thyroid Gland Follicular Carcinoma1
GNAS R201H	Radioactive Iodine	Predictive	C	Supports Sensitivity Response	3	accepted	EID3045 A 79 year old patient with prior 5-year history of Graves' disease presented with follicular thyroid carcinoma. Two mutations NRAS p.Q61K and GNAS p.R201H were detected. The thyroid cancer manifested … (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.