Variant · Snv

GNAS R201C

CI-VAR-00003754Explore in graph →NP_000507.1:p.Arg201CysNM_000516.5:c.601C>TClinVar 15933 CIViC 826 rs11554273

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
BRAF V600E AND GNAS R201C	Cetuximab + Irinotecan + VemurafenibCombination	Predictive	C	Supports Resistance	2	accepted	EID1906 Phase 1b study of vemurafenib, cetuximab and irinotecan in 19 BRAF V600E mutant colorectal cancer patients. cfDNA panel sequencing was performed in 10 patients after disease progression. One patient a… (full text at CIViC) PMID 27729313 · Hong et al., 2016 · Open in CIViC	civic
Malignant Pancreatic Neoplasm1
KRAS G12D AND GNAS R201C AND NF1 D1976fs	Trametinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID11714 In this clinical trial, 18 patients with pancreatic cancer were recruited. In this case, the patient (82 y/F) with pancreatic cancer harboring GNAS R201C, KRAS G12D and, NF1 D1976fs, was treated with …

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
15933	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	McCune-Albright syndrome; Sex cord-stromal tumor; Neoplasm; Pituitary adenoma 3, multiple types; ACTH-independent macronodular adrenal hyperplasia 1; Pseudohypoparathyroidism type 1B; GNAS-related disorder	germline/somatic	10	Nov 09, 2025