FLG

filaggrin

Identifier: CI-GENE-00002026
Entity page: /gene/FLG ↗
Edges: 28

Neighbours: 24 cancers4 variants
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FLG has variant …HAS_VARIANTderived4 of 4
→ has variant	NM_002016.2(FLG):c.1945G>T (p.Ala649Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002016.2(FLG):c.3896G>A (p.Arg1299Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

FLG altered in cohorts of …ALTERED_INderived24 of 24show fewer
→ altered in cohorts of	Hepatocellular Carcinoma 273 / 377 cases (72 %) · ssm · TCGA-LIHC · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinoma 406 / 573 cases (71 %) · ssm · TCGA-LUAD · largest of 9 cohorts	—	—	Lung Adenocarcinoma	9	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 75 / 126 cases (60 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 283 / 559 cases (51 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Wilms Tumor 22 / 51 cases (43 %) · ssm · MP2PRT-WT	—	—	Wilms Tumor	1	Observed	gdc	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 29 / 83 cases (35 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 143 / 469 cases (30 %) · ssm · skcm_tcga_gdc · largest of 7 cohorts	—	—	Cutaneous Melanoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 40 / 144 cases (28 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 253 / 1,144 cases (22 %) · ssm · nsclc_tcga_broad_2016	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 108 / 518 cases (21 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 86 / 478 cases (18 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 84 / 484 cases (17 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 32 / 185 cases (17 %) · ssm · esca_tcga · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 38 / 247 cases (15 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 24 / 158 cases (15 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 38 / 291 cases (13 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Cervical Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 67 / 515 cases (13 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 53 / 429 cases (12 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 116 / 1,015 cases (11 %) · ssm · crc_sysucc_2022 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 53 / 474 cases (11 %) · ssm · blca_msk_tcga_2020 · largest of 7 cohorts	—	—	Bladder Urothelial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 61 / 629 cases (9.7 %) · ssm · difg_glass · largest of 6 cohorts	—	—	Diffuse Glioma	6	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 22 / 297 cases (7.4 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 66 / 1,066 cases (6.2 %) · ssm · brca_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Invasive Breast Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 30 / 523 cases (5.7 %) · ssm · ov_tcga_pan_can_atlas_2018	—	—	High-Grade Serous Ovarian Cancer	1	Observed	cbioportal	graph →

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