ESR1

estrogen receptor 1

Identifier: CI-GENE-00001027
Entity page: /gene/ESR1 ↗
Edges: 46

Neighbours: 2 cancers33 variants9 drugs
Drawn: 44 of 44 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ESR1 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Malignant Breast Neoplasmcancer_family	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ associated with	Malignant Breast Neoplasmcancer_family 2 source records aggregated	supports

ESR1 targets …TARGETS9 of 9
← targets	Toremifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →
← targets	Tamoxifensmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →
← targets	Lasofoxifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →
← targets	Fulvestrantsmall_molecule	—	ANTAGONIST\|DEGRADER	—	1	Curated	chembl	graph →
← targets	Elacestrantsmall_molecule	—	DEGRADER	—	1	Curated	chembl	graph →
← targets	Diethylstilbestrolsmall_molecule	—	AGONIST	—	1	Curated	chembl	graph →
← targets	Camizestrantsmall_molecule	—	DEGRADER	—	1	Curated	chembl	graph →
← targets	Bazedoxifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →
← targets	Afimoxifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →

ESR1 targets …TARGETS9 of 9

← targets

Toremifenesmall_molecule

—

MODULATOR

—

Curated

ESR1 has variant …HAS_VARIANTderived33 of 33show fewer
→ has variant	D538GSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	3	Curated	civic	graph →
→ has variant	L536QSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Y537CSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Y537NSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Y537SSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	S463PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E380QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Expressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H524LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L370FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L469VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L536HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L536PSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L536RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1069A>G (p.Met357Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1138G>C (p.Glu380Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1236-112A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1610A>C (p.Tyr537Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1610A>G (p.Tyr537Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1613A>G (p.Asp538Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.172G>A (p.Ala58Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.1782G>A (p.Thr594=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.30T>C (p.Ser10=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.433G>A (p.Gly145Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.453-9deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.643+63C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.804G>C (p.Lys268Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.908A>G (p.Lys303Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000125.4(ESR1):c.988G>A (p.Glu330Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Y537DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

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