ERBB4

← targets

Tarloxotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Poziotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Neratinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Dacomitinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Dacomitinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Canertinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Afatinibsmall_molecule

—

INHIBITOR

—

Curated

Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma

ERBB4 has variant …HAS_VARIANTderived15 of 18show all (up to 200)
→ has variant	EXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma	2	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	NUCLEAR TRANSLOCATIONstructural 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	e26::e18fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E317KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E715KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G1109CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K935ISNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.1122T>G (p.His374Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.1199-4G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.234+169A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.2965-7_2965-4delother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.3861G>T (p.Glu1287Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005235.3(ERBB4):c.421+58A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

ERBB4 has variant …HAS_VARIANTderived15 of 18show all (up to 200)

→ has variant

EXPRESSIONexpression

2 accepted CIViC evidence items

—

Curated

→ has variant

Mutationother

1 accepted CIViC evidence items

—

Melanoma

Curated

Malignant Breast Neoplasm

→ has variant

NUCLEAR TRANSLOCATIONstructural

1 accepted CIViC evidence items

—

Curated

→ has variant

e26::e18fusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E317KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E715KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Fusionfusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G1109CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K935ISNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_005235.3(ERBB4):c.1122T>G (p.His374Gln)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_005235.3(ERBB4):c.1199-4G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_005235.3(ERBB4):c.234+169A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_005235.3(ERBB4):c.2965-7_2965-4delother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_005235.3(ERBB4):c.3861G>T (p.Glu1287Asp)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_005235.3(ERBB4):c.421+58A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

Skin Squamous Cell Carcinoma

ERBB4 altered in cohorts of …ALTERED_INderived15 of 15
→ altered in cohorts of	Skin Squamous Cell Carcinoma 20 / 39 cases (51 %) · ssm · cscc_hgsc_bcm_2014	—	—	Skin Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 109 / 293 cases (37 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 161 / 696 cases (23 %) · ssm · mel_mskimpact_2020 · largest of 5 cohorts	—	—	Cutaneous Melanoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Melanomacancer_family 23 / 144 cases (16 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 21 / 181 cases (12 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 60 / 518 cases (12 %) · ssm · stes_tcga_pub · largest of 3 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 49 / 478 cases (10 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 43 / 429 cases (10 %) · ssm · coad_tcga_gdc	—	—	Colon Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 42 / 484 cases (8.7 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Lung Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 99 / 1,144 cases (8.7 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 37 / 527 cases (7.0 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 31 / 474 cases (6.5 %) · ssm · blca_msk_tcga_2020	—	—	Bladder Urothelial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 429 / 7,237 cases (5.9 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 64 / 1,134 cases (5.6 %) · ssm · crc_msk_2017 · largest of 3 cohorts	—	—	Colorectal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 142 / 2,653 cases (5.4 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 2 cohorts	—	—	Lung Adenocarcinoma	2	Observed	cbioportal	graph →

ERBB4 altered in cohorts of …ALTERED_INderived15 of 15

→ altered in cohorts of

20 / 39 cases (51 %) · ssm · cscc_hgsc_bcm_2014

—

Skin Squamous Cell Carcinoma

Observed

cbioportal