ERBB2

erb-b2 receptor tyrosine kinase 2

Identifier: CI-GENE-00044905
Entity page: /gene/ERBB2 ↗
Edges: 263

Neighbours: 16 cancers15 variants20 drugs
Drawn: 51 of 51 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ERBB2 associated with …ASSOCIATED_WITH15 of 36show all (up to 200)
→ associated with	Lung Non-Small Cell Carcinomasubtype 20 source records aggregated	supports	A	Lung Non-Small Cell Carcinoma	20	Curated	civic	graph →
→ associated with	HER2-Positive Breast Carcinoma

ERBB2 targets …TARGETS20 of 20show fewer
← targets	Zenocutuzumab-zbcomonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Zanidatamabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tucatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Trastuzumab Emtansineadc	—	BINDING AGENT	—	1	Curated	chembl	graph →
← targets	Trastuzumab Deruxtecanadc	—	BINDING AGENT	—	1	Curated	chembl	graph →
← targets	Trastuzumab Deruxtecanadc	—	BINDING AGENT	—	1	Curated	chembl	graph →
← targets	Trastuzumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tarloxotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pyrotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Poziotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pertuzumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Neratinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Margetuximabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lapatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Disitamab Vedotinadc	—	BINDING AGENT	—	1	Curated	chembl	graph →
← targets	Dacomitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dacomitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Canertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Afatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

ERBB2 targets …TARGETS20 of 20show fewer

← targets

Zenocutuzumab-zbcomonoclonal_antibody

—

INHIBITOR

—

Curated

ERBB2 has variant …HAS_VARIANTderived15 of 202show all (up to 200)
→ has variant	Amplificationamplification 65 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Gastric Neoplasm,Malignant Pancreatic Neoplasm+2	65	Curated	civic	graph →
→ has variant	Overexpressionexpression 7 accepted CIViC evidence items	—	—	Solid Neoplasm,Malignant Pancreatic Neoplasm,Malignant Salivary Gland Neoplasm+2	7	Curated	civic	graph →
→ has variant	Y772_A775DUPinsertion 7 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma,Lung Adenosquamous Carcinoma	7	Curated	civic	graph →
→ has variant	G778_P780dup 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	6	Curated	civic	graph →
→ has variant	L755SSNV 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Colorectal Adenocarcinoma+2	6	Curated	civic	graph →
→ has variant	MutationSNV 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm+1	6	Curated	civic	graph →
→ has variant	V777LSNV 5 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Malignant Colorectal Neoplasm+1	5	Curated	civic	graph →
→ has variant	R678QSNV 4 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Gastric Adenocarcinoma	4	Curated	civic	graph →
→ has variant	D769YSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Extramammary Paget Disease	3	Curated	civic	graph →
→ has variant	Exon 20 Insertioninsertion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	G776delinsVCindel 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	Kinase Domain Mutation 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	L755PSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	S310FSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	G776delinsLCindel 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →

ERBB2 altered in cohorts of …ALTERED_INderived5 of 5
→ altered in cohorts of	Endometrial Carcinoma 28 / 181 cases (15 %) · ssm · ucec_ccr_msk_2022 · largest of 2 cohorts	—	—	Endometrial Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 70 / 474 cases (15 %) · ssm · blca_msk_tcga_2020 · largest of 7 cohorts	—	—	Bladder Urothelial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 51 / 527 cases (9.7 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 378 / 7,237 cases (5.2 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 36 / 696 cases (5.2 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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