CREBBP

CREB binding lysine acetyltransferase

Identifier: CI-GENE-00042201
Entity page: /gene/CREBBP ↗
Edges: 77

Neighbours: 19 cancers15 variants
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CREBBP associated with …ASSOCIATED_WITH2 of 2
→ associated with	Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBPmolecular_subtype 2 source records aggregated	supports	B	Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP	2	Curated	civic	graph →
→ associated with	Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP

CREBBP has variant …HAS_VARIANTderived15 of 57show all (up to 200)
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP	3	Curated	civic	graph →
→ has variant	Deletiondeletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	HAT mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1253dup (p.His418fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1331-32G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1474T>A (p.Tyr492Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.166del (p.Ser56fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1676+2T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1824-1G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1824-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.1915G>T (p.Asp639Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.223C>T (p.Arg75Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.2283+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004380.3(CREBBP):c.2283+2T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

CREBBP has variant …HAS_VARIANTderived15 of 57show all (up to 200)

→ has variant

Fusionfusion

3 accepted CIViC evidence items

—

Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP

Curated

CREBBP altered in cohorts of …ALTERED_INderived18 of 18show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 70 / 293 cases (24 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 180 / 755 cases (24 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Pelvis and Ureter Urothelial Carcinoma 21 / 119 cases (18 %) · ssm · utuc_msk_2019	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 67 / 511 cases (13 %) · ssm · ucec_tcga_gdc · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 56 / 474 cases (12 %) · ssm · blca_msk_tcga_2020 · largest of 8 cohorts	—	—	Bladder Urothelial Carcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 115 / 1,001 cases (11 %) · ssm · dlbcl_duke_2017 · largest of 2 cohorts	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 67 / 696 cases (9.6 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 98 / 1,049 cases (9.3 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 40 / 429 cases (9.3 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 45 / 527 cases (8.5 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 44 / 518 cases (8.5 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 26 / 322 cases (8.1 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 38 / 478 cases (7.9 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 23 / 291 cases (7.9 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 517 / 7,237 cases (7.1 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 30 / 515 cases (5.8 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 35 / 629 cases (5.6 %) · ssm · difg_glass · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 57 / 1,134 cases (5.0 %) · ssm · crc_msk_2017 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →

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