CREBBP Deletion

CI-VAR-00000635Explore in graph →CIViC 856

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
CREBBP Deletion	C646	Predictive	D	Supports Sensitivity Response	3	submitted	EID1965 Ablation of the CBP paralog p300/EP300 has been identified as syntheticaly lethal in in CBP-knockout and CBP-deficient cancer cells and induced a G1-S cell-cycle arrest, followed by apoptosis. Genome-… (full text at CIViC) PMID 26603525 · Ogiwara et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.