AURKA

aurora kinase A

Identifier: CI-GENE-00021483
Entity page: /gene/AURKA ↗
Edges: 15

Neighbours: 6 cancers7 variants2 drugs
Drawn: 15 of 15 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
AURKA associated with …ASSOCIATED_WITH6 of 6
→ associated with	Esophageal Squamous Cell Carcinomasubtype	supports	B	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ associated with	Ovarian Serous Adenocarcinomasubtype	supports	B

AURKA targets …TARGETS2 of 2
← targets	Tozasertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Alisertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

AURKA targets …TARGETS2 of 2

← targets

Tozasertibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

← targets

Alisertibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

AURKA has variant …HAS_VARIANTderived7 of 7
→ has variant	Overexpressionexpression 3 accepted CIViC evidence items	—	—	Cervical Adenocarcinoma,Lung Non-Small Cell Carcinoma,Ovarian Serous Adenocarcinoma	3	Curated	civic	graph →
→ has variant	EXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Esophageal Squamous Cell Carcinoma,Ovarian Carcinoma	2	Curated	civic	graph →
→ has variant	Amplificationamplification 1 accepted CIViC evidence items	—	—	Esophageal Adenocarcinoma	1	Curated	civic	graph →
→ has variant	NM_198437.3(AURKA):c.1038C>A (p.Phe346Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_198437.3(AURKA):c.1085G>T (p.Arg362Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_198437.3(AURKA):c.-5-7T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_198437.3(AURKA):c.91T>A (p.Phe31Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

AURKA has variant …HAS_VARIANTderived7 of 7

→ has variant

Overexpressionexpression

3 accepted CIViC evidence items

—

Cervical Adenocarcinoma,Lung Non-Small Cell Carcinoma,Ovarian Serous Adenocarcinoma

Curated

civic

graph →

→ has variant

EXPRESSIONexpression

2 accepted CIViC evidence items