Drug · Small Molecule
Tozasertib
CI-DRUG-00000600Explore in graph →NCIt C98053 CHEMBL572878 CIViC Phase 2
Regulatory
Approvals (0)
Each record names the authority, jurisdiction, indication text and status. A drug approved in one jurisdiction for one indication is not 'approved' in general.
Data not yet available
Derived
Development pipeline
Most advanced stage across all cancers, then per top-level cancer reached through trial conditions or approval indications. Approval in any ingested jurisdiction outranks trial phase; counts are interventional studies.
| Scope | Stage | Max phase | Active | Recruiting | Phase 3 | Trials | Approvals | Jurisdictions | First approval | First trial |
|---|---|---|---|---|---|---|---|---|---|---|
| All cancers | Phase1 | Phase 1 | 0 | 0 | 0 | 1 | 0 | — | — | 2005-05 |
- Source
- clinicaltrials
- Layer
- derived (computed by CancerIndex)
Data updated 17 hours agoSource updated unknown
Curated evidence
Clinical evidence (1)
CIViC items in which this therapy appears, grouped by cancer context, then molecular profile. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28102363
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SMARCA4 INACTIVATING MUTATION1 | ||||||||
| Tozasertib | ||||||||
Clinical trials
Trials with this intervention (1)
Most recently updated first, 50 per page.
- Source
- ClinicalTrials.gov
- Dataset
- ClinicalTrials.gov API v2 studies
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02532868 | A VX-680 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Cancer (0457-002) | terminated | Phase 1 | 27 | Merck Sharp & Dohme LLCINDUSTRY | 0 | Aug 26, 2015 | clinicaltrials |