AR

androgen receptor

Identifier: CI-GENE-00011134
Entity page: /gene/AR ↗
Edges: 117

Neighbours: 7 cancers15 variants9 drugs
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
AR associated with …ASSOCIATED_WITH4 of 4
→ associated with	Malignant Prostate Neoplasmcancer 5 source records aggregated	supports	B	Malignant Prostate Neoplasm	5	Curated	civic	graph →
→ associated with	Malignant Prostate Neoplasmcancer 4 source records aggregated

AR targets …TARGETS9 of 9
← targets	Nilutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Galeteronesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Flutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Enzalutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Darolutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Cyproterone Acetatesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Bicalutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Apalutamidesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Abirateronesmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →

AR has variant …HAS_VARIANTderived15 of 100show all (up to 200)
→ has variant	AR-V7splice 7 accepted CIViC evidence items	—	—	Malignant Prostate Neoplasm	7	Curated	civic	graph →
→ has variant	F877LSNV 1 accepted CIViC evidence items	—	—	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ has variant	OVEREXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	R726LSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	W742SNV 1 accepted CIViC evidence items	—	—	Prostate Carcinoma	1	Curated	civic	graph →
→ has variant	A234TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A748VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A765TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	AR alternative transcripts no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D221HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D528GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E198GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	EXPRESSIONexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F876LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

AR altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Skin Basal Cell Carcinoma 49 / 293 cases (17 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 61 / 444 cases (14 %) · ssm · prad_su2c_2019 · largest of 2 cohorts	—	—	Prostate Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 49 / 696 cases (7.0 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 365 / 7,237 cases (5.0 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths