AR D221H

CI-VAR-00000454Explore in graph →CIViC 3706

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
AR D221H	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID10115 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.