ALK

ALK receptor tyrosine kinase

Identifier: CI-GENE-00000942
Entity page: /gene/ALK ↗
Edges: 6,390

Neighbours: 15 cancers15 variants7 drugs
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ALK associated with …ASSOCIATED_WITH15 of 33show all (up to 200)
→ associated with	Lung Non-Small Cell Carcinomasubtype 9 source records aggregated	supports	A	Lung Non-Small Cell Carcinoma	9	Curated	civic	graph →
→ associated with	Inflammatory Myofibroblastic Tumor

ALK targets …TARGETS7 of 7
← targets	Lorlatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Entrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ensartinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Crizotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ceritinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Brigatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Alectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

ALK has variant …HAS_VARIANTderived15 of 6,343show all (up to 200)
→ has variant	Fusionfusion 52 accepted CIViC evidence items	—	—	Malignant Neoplasm,Pleural Malignant Mesothelioma,Lung Non-Small Cell Carcinoma+2	52	Curated	civic	graph →
→ has variant	Fusionfusion 43 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Anaplastic Large Cell Lymphoma+2	43	Curated	civic	graph →
→ has variant	F1174LSNV 9 accepted CIViC evidence items	—	—	Inflammatory Myofibroblastic Tumor,Lung Non-Small Cell Carcinoma,Neuroblastoma	9	Curated	civic	graph →
→ has variant	e6::e20fusion 8 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma	8	Curated	civic	graph →
→ has variant	C1156YSNV 7 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	7	Curated	civic	graph →
→ has variant	G1202RSNV 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Pleural Malignant Mesothelioma,Lung Non-Small Cell Carcinoma+1	7	Curated	civic	graph →
→ has variant	G1269ASNV 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	7	Curated	civic	graph →
→ has variant	I1171SNV 7 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	7	Curated	civic	graph →
→ has variant	L1196MSNV 7 accepted CIViC evidence items	—	—	Pleural Malignant Mesothelioma,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	7	Curated	civic	graph →
→ has variant	R1275QSNV 6 accepted CIViC evidence items	—	—	Neuroblastoma	6	Curated	civic	graph →
→ has variant	F1245CSNV 5 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Neuroblastoma	5	Curated	civic	graph →
→ has variant	V1180LSNV 5 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	5	Curated	civic	graph →
→ has variant	I1171NSNV 4 accepted CIViC evidence items	—	—	Pleural Malignant Mesothelioma,Lung Non-Small Cell Carcinoma	4	Curated	civic	graph →
→ has variant	T1151dupinsertion 4 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	4	Curated	civic	graph →
→ has variant	Amplificationamplification 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →

ALK altered in cohorts of …ALTERED_INderived7 of 7
→ altered in cohorts of	Skin Basal Cell Carcinoma 50 / 293 cases (17 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 115 / 696 cases (17 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 26 / 181 cases (14 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Neuroblastomasubtype 64 / 471 cases (14 %) · ssm · nbl_target_gdc · largest of 3 cohorts	—	—	Neuroblastoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 24 / 322 cases (7.5 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 32 / 527 cases (6.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 388 / 7,237 cases (5.4 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths