AHNAK2

AHNAK nucleoprotein 2

Identifier: CI-GENE-00000743
Entity page: /gene/AHNAK2 ↗
Edges: 25

Neighbours: 22 cancers3 variants
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
AHNAK2 has variant …HAS_VARIANTderived3 of 3
→ has variant	NM_138420.4(AHNAK2):c.12355C>G (p.Leu4119Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_138420.4(AHNAK2):c.14018A>T (p.His4673Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

AHNAK2 altered in cohorts of …ALTERED_INderived22 of 22show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 24 / 39 cases (62 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 68 / 126 cases (54 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 56 / 158 cases (35 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 100 / 517 cases (19 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 25 / 144 cases (17 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 395 / 2,433 cases (16 %) · ssm · brca_metabric	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 75 / 469 cases (16 %) · ssm · skcm_tcga_gdc · largest of 4 cohorts	—	—	Cutaneous Melanoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 83 / 566 cases (15 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 7 cohorts	—	—	Lung Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 67 / 518 cases (13 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 143 / 1,144 cases (13 %) · ssm · nsclc_tcga_broad_2016	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 60 / 484 cases (12 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 58 / 478 cases (12 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 28 / 247 cases (11 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 46 / 429 cases (11 %) · ssm · coad_tcga_gdc · largest of 3 cohorts	—	—	Colon Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 56 / 629 cases (8.9 %) · ssm · difg_glass · largest of 4 cohorts	—	—	Diffuse Glioma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 42 / 474 cases (8.9 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 24 / 291 cases (8.2 %) · ssm · cesc_tcga_pan_can_atlas_2018	—	—	Cervical Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 82 / 1,015 cases (8.1 %) · ssm · crc_sysucc_2022 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 35 / 444 cases (7.9 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 26 / 373 cases (7.0 %) · ssm · lihc_tcga · largest of 2 cohorts	—	—	Hepatocellular Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 35 / 515 cases (6.8 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 30 / 523 cases (5.7 %) · ssm · ov_tcga_pan_can_atlas_2018	—	—	High-Grade Serous Ovarian Cancer	1	Observed	cbioportal	graph →

AHNAK2 altered in cohorts of …ALTERED_INderived22 of 22show fewer

→ altered in cohorts of

Skin Squamous Cell Carcinoma

24 / 39 cases (62 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts

—

Skin Squamous Cell Carcinoma

Observed

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