Ziftomenib

small molecule

Identifier: CI-DRUG-00000652
Entity page: /drug/ziftomenib ↗
Edges: 34

Neighbours: 15 cancers10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Ziftomenib approved for …APPROVED_FOR1 of 1
→ approved for	Acute Myeloid Leukemiahematologic_malignancy	supports	FDA ORIG	Acute Myeloid Leukemia	1	Regulatory	openfda	graph →
Ziftomenib investigated for …INVESTIGATED_FOR4 of 4
investigated for

Ziftomenib investigated in trials for …INVESTIGATED_IN_TRIALSderived13 of 13
→ investigated in trials for	Acute Myeloid Leukemiahematologic_malignancy 11 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemia 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia with NPM1 Mutation 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia of Ambiguous Lineage 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia of Ambiguous Lineage	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastrointestinal Stromal Tumor 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemiacancer_family 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastrointestinal Stromal Tumor 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Mixed Phenotype Acute Leukemia 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mixed Phenotype Acute Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Myeloid Leukemia 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Myeloid Sarcoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myeloid Sarcoma	1	Observed	clinicaltrials	graph →

Ziftomenib investigated in trials for …INVESTIGATED_IN_TRIALSderived13 of 13

→ investigated in trials for

Acute Myeloid Leukemiahematologic_malignancy

11 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Acute Myeloid Leukemia

Observed

Ziftomenib studied in …STUDIED_INderived10 of 16show all (up to 200)
→ studied in	NCT06769490Phase 1 · recruiting Dose Escalation and Expansion of Ziftomenib in Combination With Quizartinib in Acute Myeloid Leukemia · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06397027Phase 1 · recruiting A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias · 16 trials list this drug (15 active)	—	—	Acute Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06930352Phase 2 · recruiting Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Eligible for Standard Therapy · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07411586Phase 1 · active not recruiting Phase 1/1b Trial Of Olutasidenib And Ziftomenib For NPM1 And IDH1 Co-Mutated Acute Myeloid Leukemia · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06001788Phase 1 · recruiting Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia · 16 trials list this drug (15 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Leukemia,Acute Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT07007312Phase 3 · recruiting Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05738538available Expanded Access to Ziftomenib · 16 trials list this drug (15 active)	—	—	Acute Lymphoblastic Leukemia,Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06448013Phase 1 · recruiting A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05848687Phase 1/Phase 2 · recruiting TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II · 16 trials list this drug (15 active)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07623616Phase 2 · recruiting A Phase 2 Clinical Study of Ziftomenib in Patients With Relapsed or Refractory NPM1-Mutated Acute Myeloid Leukemia · 16 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →

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